Neoplastic MSK disease
SNSA
Lupus and Myositis
Embryology
Variety
100
Most common benign bone tumor
What is osteochondroma?
100
Name the seronegative spondyloarthritic disease knwon to cause restrictive lung disease.
What is ankylosing spondylitis?
100
Dermatomyositis and polymyositis are associated with proximal muscles weakness. Name the specific lab value that will be elevated in patients with these conditions?
What is creatine kinase?
100
Muscle cells for the limbs are derived from somites and segments of lateral plate mesoderm that are located at specific levels. For the upper limb these blocks are ____________ and for the lower limb, these blocks are _____________.
What are C4 or C5?
What are T1 or T2?
100
Guess the medical disease/disorder based on the emojis below.
💅🏻🌭🦴
What is Psoriatic arthritis?
200
X-ray reveals lytic, expansile oval lesions with a thin slerotic rim (O-ring). Grossly, the lesion is well circumscribed and has the pale blue appearance of typical cartilage. Name this primary bone tumor.
What is chondroma?
200
What is the classic triad for reactive arthritis?
What is conjunctivitis, urethritis, and arthritis?
200
The lesions of greatest clinical importance in SLE are those in the...
What are the kidneys?
200
During fetal development, the rotation of the limbs occurs at which week?
What is week 7?
200
Guess the medical disease/disorder based on the emojis below.
🤰🏼💪🏻💦
What is Prune belly syndrome?
300
Histologically is composed of a mixture of mononuclear cells and osteoclast like giant cells. Additionally, you will see calcification around individual cells often referred to as "chicken wire" calcification. Name the primary bone tumor.
What is chondroblastoma?
300
All seronegative spondyloarthropathies are associated with which genetic marker?
What is HLA-B27 ?
300
A 31-year-old woman presents to her primary care physician with a 2-month history of joint pain. She says that she has been getting increasing joint pain in her hands and feet that has been interfering with her ability to work as a secretary. Furthermore, she has noticed that she has been getting numerous oral ulcers over the same time period even though she never had ulcers before. Her husband is worried because she sometimes appears to be confused and acts erratically during these times. Physical exam reveals edema of the legs bilaterally and a new systolic murmur best heard in the right upper sternal border around the second rib. Which type of hypersensitivity is most likely responsible for this patient's edema?
What is type III hypersensitivity?
RASH OR PAIN:
Rash
Arthritis (nonerosive)
Serositis (eg, pleuritis, pericarditis) Hematologic disorders (eg, cytopenias) Oral/nasopharyngeal ulcers (usually painless) Renal disease
Photosensitivity
Antinuclear antibodies
Immunologic disorder (anti-dsDNA, anti-Sm, antiphospholipid)
Neurologic disorders (eg, seizures, psychosis)
300
Amniotic bands are tears in the amnion which result from __________ or _________ may encircle parts of the fetus and form bands which constrict fetal structures such as fingers or limbs resulting in ring constrictions or amputations.
What is infections or toxins?
300
Guess the medical disease/disorder based on the emojis below.
🦋👅😵💫
What is SLE?
400
Both Ollier's disease and Maffuci syndrome are associated with enchondromas and present early in life. They are both associated with what mutation?
What is isocitrate dehydrogenase 1 or 2
400
A patient has arthritis findings predominantly at the DIPs. Their fingers could be described as "sausage digits" another term for dactylitis. What would the patient most likely be diagnosed with?
What is psoriatic arthritis?
400
A 40-year-old male presents to your office complaining that he is too weak to climb stairs or brush his hair. He denies any headaches or change in vision. A muscle biopsy reveals CD8+ lymphocyte infiltration in the endomysium. What is the most likely diagnosis?
What is polymyositis?
400
The majority of bones in the body form through endochondral ossification. What are the exceptions?
what are the bones of the skull (face and cranium) and the calvicles?
400
If you could be any disease we have learned about so far what would it be?
:)
500
7. A 17-year-old boy presents with pain and swelling about the left knee for the past month. He thought that this condition resulted from an old football injury and that it would resolve without incident. The pain, however, has persisted and is severe enough to cause him to limp. Radiographs of the knee demonstrate a lifting of the periosteum and a spiculated “sunburst” pattern in the distal femur. Which of the following is the most likely diagnosis?
A. Osteosarcoma
B. Chondrosarcoma
C. Ewing sarcoma
D. Giant cell tumor
E. Knee sprain
What is osteosarcoma?
500
The first line of treatment for spondyloarthropathies is NSAIDs used to reduce pain and inflammation. Name the 3 DMARDs that would be beneficial in patients with SNSA?
What is Sulfasalazine, methotrexate, and leflunomide?
500
A 41-year-old female presents to her primary care doctor with worsening muscle pain and weakness. Approximately two months ago, she reports the recent development of having difficulty climbing stairs and raising her arms above her head. Additionally, there was a dull aching pain in her shoulders over the same time period. Her family history is notable for systemic lupus erythematosus in her mother. Physical examination demonstrates symmetric muscle weakness in hip flexion, hip extension, and shoulder abduction. She has red scaly skin overlying the extensor joints of her fingers and has another dermatological finding seen in Figure A. Which of the following is associated with this patient’s most likely condition?
A. Anti-CCP antibody
B. Anti-topoisomerase I antibody
C. Perimysial inflammation with infiltration of CD4+ T-cells
D. Endomysial inflammation with infiltration of CD8+ T-cells
E. Loss of dystrophin expression
What is C. Perimyseal inflammation with infiltration of CD4+ T cells?
500
Signaling structure at the tip of the limb bud that signals mesenchyme to proliferate and the limb grows.
What is the apical ectodermal ridge (AER)?
500
Amanda's middle name
What is Michelle?