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In epigenetics, the tighter DNA is wound around nucleosomes the less that DNA is used. If a histone protein gets an epigenetic tag that has a -1 charge, will the DNA around that nucelosome be upregulated or downregulated?
What is upregulated? (Because phosphates on outside of DNA have a - charge, -/- repulse, so DNA will not be tightly wrapped around nucleosome = DNA used more = upregulated.