Package Insert
At 3.5 years, what % of ami+laz patients were alive in vs 44% of osi patients, marking this the 1st and only treatment to achieve stat. sign. OS benefit over osi!!
56%
Patients received 4 cycles of what before reaching their maintenance dose in the osi + chemo arm?
Carboplatin OR cisplatin
What is the most common EGFR-dependent resistance mechanism?
C797S mutation
At what age is it recommended to get lung cancer screening if patients have a history of smoking?
50
In what month is our fearless leader, Marty's, birthday?
February
What is the mPFS for ami + chemo in MARIPOSA 2 that translated to a 52% reduction in progression or death?
How often were brain scans performed in FLUARA 2 and what patients received these scans?
Every 12 weeks (3 months) with tumor assessments after initial screening, only patients with baseline brain mets.
Which biomarker of high risk disease had the highest reduction in risk of progression or death in the MARIPOSA post hoc analysis?
Liver mets at 42%
Metastasis to these tissues covering the brain and spinal cord occurs in 5-15% of lung cancer patients and is associated with a median survival of 3-6 months.
Leptomeninges
This year marks the _____ anniversary of Paul Revere's ride through Boston.
250th
Amivantamab activates this process in which antibodies bind to cancer cells and and recruit NK cells to destroy the cancer cells.
Antibody-dependent cellular cytotoxicity (ADCC)
What was the PFS in patients with CSN mets in FLAURA2?
24.9 months
Detectable EGFR+ ctDNA is present in what % of NSCLC patients?
75%
What is the name of the clinical trial evaluating osimertinib in the neoadjuvant setting?
NeoADAURA
What country was an ally to America during the Revolutionary War?
France
Only infusion bags made of what 4 materials can be used for Rybrevant?
PP, PE, PVC, PP+PE
In what 2 patient subgroups/endpoints did osi + chemo not show a benefit compared to osi monotherapy?
High tumor burden and TP53 patients
TP53 co-mutation can be present in up to 50% of NSCLC patients, what is it's primary role in the body's cells?
Tumor suppression and regulating apoptosis
Adjuvant patients who have undergone surgical resection
What's the oldest bar in Boston where we should have our next Revolutionaries meeting?
The Bell in Hand Tavern
What was the rate (%) of Grade 3 derm reactions in patients with the COCOON protocol vs standard skincare management?
4.3% (vs 8.8%)
Although we can't compliantly discuss this....the duration of treatment for ami+laz was ~18 months, what was it for osi + chemo?
~8 months
In MARIPOSA, what is the icDOR in confirmed responders for ami + laz with lesions at baseline?
35.7 months vs 29.6
Name a new oral 4th gen TKI in trials for NSCLC Exon20 patients?
Zipalertinib or Sunvozertinib
What event is considered the start of the Revolutionary War?