Treatment
Clinical Presentation
OA vs RA
Lab/Genetic Markers
Two Truths and A Lie
100

This is the most common cause of adrenal insufficiency.

What is abrupt glucocorticoid cessation?

100

This disease presents with genu varum (“bow legs”) and diminished growth, and is a sign of severe vitamin D deficiency in children. 

What is Rickets?



100

Autoimmune disease where the body's immune system mistakenly attacks the synovium

What is RA?
100

This genetic marker is characteristic of many spondyloarthropathies.

What is HLA-B27?

100

I am a medication that contributes to osteoporosis.

1. I am a glucocorticoid

2. I am an anticonvulsant.

3. I am a diuretic.


What is a diuretic? Good question. Ask Jayesh.

200

This supplement is recommended for patients on chronic low-dose methotrexate.

What is folic acid?

200

These 2 bacteria are the most common offenders in septic arthritis.

Staphylococcus aureus and Neisseria gonorrhea



200

Chronic inflammation of multiple joints

What is RA

200

This is the diagnostic WBC count for Septic Arthritis.

What is >100,000?

200

I am ANA

  1. I stand for antinuclear antibody

  2. I am specific for RA

  3. I am found in healthy peeps

What is specific for RA? Not sure, Jayesh probably knows though.
300

Methotrexate, the initial treatment for active RA, is contraindicated in these populations (name two).

What are pregnant women, individuals with liver disease or severe renal impairment, alcoholism, preexisting bone marrow suppression



300

This pattern of joint involvement is most indicative of spondyloarthropathy or idiopathic juvenile arthritis.

What is oligoarthritis?



300

NSAIDS are common medications used to assist this pathology

What is OA?

300

This is the standard PMN percentage for OA.

What is 25%?

300

Stats break!

  1. Approximately 50 to 70 percent of women with rheumatoid arthritis (RA) improve during pregnancy.

  2. Andrew’s source this week was page 802 in the Washington Manual.

  3. By the year 2040, more than 78 million Americans are expected to have an arthritis diagnosis.

Why did you think Andrew's reference page was 802? It was obviously 902.

400

Cigarette smoking induces the expression of these enzymes in the lung.

What are peptidylarginine deiminase (PAD) enzymes



400

These names are the term for osteophytes on interphalangeal joints that develop in patients with osteoarthritis.

What are Heberden nodes (DIP joints) and Bouchard nodes (PIP joints)?

400

This disease has elevated markers of inflammation. Identify the disease and tell us which 4 markers are implicated.

What are 

RA: CRP, ESR, RF, anti-CCP?



400

Anti-CCP is a marker of autoantibodies against this post translational protein modification.

What is citrullination?

400

I am RA.

1. Joint fluid clarity is opaque

2. The usual WBC/mm^3 is 2k-100k

3. PMN is often >50%

What is opaque joint fluid clarity? Not sure, but Jayesh told me he knew the answer to that so maybe check with him?



500

These anti-rheumatic biologics produce their pharmacological effects through these mechanisms of actions, respectively: Anti-CD20 B Cell, anti-TNF alpha decoy receptor, JAK 1 & 3 inhibitor.

What are Ritiximab, Etanercept, and Tofactinib 



500

This pathologic presentation of a crystal-induced arthritis refers to the accumulation of uric acid crystals in the skin and subcutaneous tissue.

What are tophi?

500

Record this, you’ll want a Clip

I hurt my Hip

    After I lean and Tip

        I like my ice cream to DIP

            My dog making sounds, Yip and PIP

What is OA?

500

This is one the binding target of C-reactive protein.

What is phosphocholine?

500

I am Jayesh.

1. I was called out in yesterday’s professionalism meeting.
2. I used to have a BMI of 12
3. Dr. Raja is my father’s cousin


Who is Dr. Raja's cousin? Because it's not my dad.