Champagne and Meaney (2006)
What is the oxytocin receptor?
This is the primary axis that the body uses to respond to stressors. +100 if you can draw it.
What is the hypothalamic-pituitary-adrenal (HPA) axis?
Stress can be both positive or negative. Give an example of a positive stressor.
Ex. Standing in front of a crowd to give a speech and hitting it out of the park.
Ex. Stressfully studying really hard for a final, then getting an A in the class.
This flavor is not sensed by taste receptors on our tongues. Sour, Spicy, Sweet, Umami, Bitter, Salty.
What is spicy?
Philly is very beautiful and full of people with artistic talent. The city is adorned with over 4,000 of these on its walls.
What is murals?
Decreased fear or "anxiety-like behavior" is operationally measured as this during the open field test.
What is increased time spent in the inner area of the open field?
The adrenal glands produce this glucocorticoid during stress.
What is cortisol?
This practice involves training attention and awareness to achieve a mentally clear and emotionally calm state, which can reduce psychological stress and anxiety.
What is meditation?
Most of our sensory systems have a projection through the brain's relay station, called the thalamus. This sensory system does not.
What is the olfactory system (sense of smell)?
What is the name of river which divides Philly into East and West? +100 if you can spell it correctly.
What is the Schuylkill River?
The study rationale is described as, "little understanding of potential mechanisms for either..."
What is the effects of environmental stressors on parental behavior?
OR
What is the intergenerational transmission of individual differences in parental care?
The Zannas et al. paper found that epigenetic age acceleration is associated with cumulative lifetime stress, but not what type(s) of stress, in an urban, African American cohort?
What is childhood or current stress?
This type of light can suppress the sleepy hormone melatonin, and decrease sleep time leading to increased stress.
What is blue light?
One of the brain cell types below is unique to the Cerebellum.
A. Microglia
B. Schwann Cells
C. Ependymal Cells
D. Purkinje Cells
What is the Purkinje cell?
Philly is known for having very passionate sports fans. These three Philadelphia sports teams have all won national championships. +100 points for each team named.
What is the Philadelphia Phillies (MLB), the Philadelphia 76ers (NBA), and the Philadelphia Flyers (NHL).
Significantly reduced levels of oxytocin receptor binding were observed in the BNST, MPOA, and cAMYG of the offspring of gestationally stressed with high LG mothers, relative to the lactating offspring of high/no-stress dams. However, these brain areas did not show significantly reduced levels of oxytocin receptor binding. Hint: there's two brain areas!
What are the lateral septum (LS) and the ventral medial hypothalamus (VMH)?
This level of childhood physical or sexual abuse was not associated with a link between cumulative life stress and Δ-age.
What is moderate to extreme child abuse?
Messages sent through this branch of the nervous system are responsible for the fight-or-flight response which makes the heart pump faster and relaxes the arterial walls that supply muscles with blood so they can respond more quickly.
What is the sympathetic nervous system (part of the Autonomic Nervous System/Involuntary)?
When imaging brain tissue sections on a slide using immunofluorescence, the DAPI stain is used to stain cell nuclei and visualize all dead cells. DAPI is typically visualized using this color.
What is blue?
This alley way in Old City is really really old, dating back to 1703, this alley is the oldest continuously inhabited residential street in the United States.
A. Elfreth's Alley
B. Drinker's Court Alley
C. Devil's Alley
D. Bradford's Alley
What is Elfreth's alley?
Draw Figure 1. to the best of your memory.
Hint! The figure legend describes an "Outline of methodology used in this study."
Jordan this is your cue to show figure 1 from the Champagne and Meaney paper :)
This process must be performed before assessing methylation levels at >480,000 CpG sites using the Illumina HumanMethylation450 BeadChip array derived from Genomic DNA extracted from whole blood from the GTP (n = 393) and the MPIP (n = 124) cohorts.
What is bisulfite conversion?
One method for managing stress describes eating a balanced diet. Foods high in essential macronutrient alongside stress can "prompt the deposition of fat around our internal organs—visceral fat that is associated with cardiovascular and metabolic diseases."
What is sugar (carbohydrates)?
This doctrine proposed by Drs. Ramón and Cajal in the 1800s is the concept that the nervous system is made up of discrete, individual cells.
What is the neuron doctrine?
This town in Pennsylvania is the mushroom capital of the world, and produces about 25% of the nation’s entire mushroom crop.
A. Pittsburgh
B. Kennett Square
C. Harrisburg
D. Altoona
What is Kennett Square?