Spectrum
cfDNA 101
Karius
Focus|BAL
Friday at 4 PM
100

This specimen type is required for Karius Spectrum testing.

What is plasma?

100

This is the type of cfDNA used to detect infections in Karius testing.

What is microbial cfDNA?

100

Karius is headquartered in this California city, where its CLIA-certified and CAP-accredited lab is located. 

What Redwood City?

100

This type of tube is used to collect and preserve BAL samples for Karius Focus | BAL testing.

What is a Streck Cell Preservative (CP) tube? 

100

This is the minimum number of patient identifiers required for a sample to be accepted for testing.

What is two? 

200

This collection tube type is in the Karius Spectrum kit.

What is a Plasma Preparation Tube (PPT)?

200

This type of cfDNA represents the majority of DNA circulating in plasma and must be distinguished from microbial cfDNA.

What is human cfDNA?

200

Karius was founded in this year.

What is 2014?

200

This is the volume of BAL fluid required for testing.

What is 1 mL?

200

True or False: A Streck CP tube may be frozen for longer stability of a BAL sample.

What is false? 

300

This step must be performed within 6 hours of blood draw.

What is centrifugation?

300

This type of cfDNA is used in non-invasive prenatal screening.

What is fetal cfDNA?

300

Karius surpassed this milestone number of patient samples tested in 2025.

What is 100,000+?

300

BAL fluid must be transferred into the Streck CP tube within this number of hours after collection.

What is 12 hours?

300

This is the minimum volume of plasma that must be transferred into a sterile polypropylene tube for Karius Spectrum testing.

What is 0.7 mL?

400

Karius Spectrum plasma samples are stable for this amount of time at ambient temperature.

What is 96 hours?

400

This is the approach used by Karius with microbial cfDNA that allows detection of infections without targeting a specific organism. 

What is pathogen-agnostic testing? 

400

This category of disease is the second leading cause of death globally.

What is infectious disease?

400

Once transferred into the Streck CP tube, BAL samples are stable at ambient temperature for this length of time.

What is 7 days? 

400

Before a BAL sample that has been frozen in a sterile, freezable tube can be sent to Karius, this must be done. 

What is thaw the sample?

500

This collection tube is used as an alternative method for Karius Spectrum sample collection.

What is a K2-EDTA (Lavender Top) tube?

500

In addition to bacteria, DNA viruses, and fungi, microbial cfDNA testing can also detect this type of organism.

What are parasites?

500

The name "Karius" comes from this children's book about 2 small "tooth trolls" that live inside cavities.

What is Karius and Baktus?

500

Karius Focus | BAL testing enables detection of this approximate number of pathogens from a single sample.

What is 500?

500

When shipping of a Karius Spectrum sample will be delayed over a holiday weekend, this is the best course of action. 

What is collect the sample and freeze it?