Review
What is the 100 year effect ?
The fact that the egg that made you was nourished by what your grandmother ate, ~100 years prior to a humans adult life.
Name two determinates of heart disease
Nephron number and hypertension, birthweight to placental weight ratio, infancy & childhood growth...
People born with more cells have higher risk for heart failure. True or False
False, People born with less cells have a higher risk.
Myocardium
The muscular tissue that forms the middle layer of the heart wall.
Share what this study reminded you of or make a connection to something you knew before.
Converse! 🗣️
Name three risk factors for heart disease and stroke.
Diabetes
Obesity
Uncontrolled hypertension
Three ways to die from a heart disease.
Heart attack, Heart Failure, Ventricular Fibrillation
There is an epigenetic effect that changes the genes in the fetus that last though adulthood that make hearts venerable and change the rate they make their cells. True or False
TRUE
Cardiomyocyte
Cardiomyocytes are the cells responsible for generating contractile force in the intact heart. (see 1.3 highlighted notes)
What seemed important about the paper?
Discuss 🗣️
At what rate did diabetes increase annually from 2010-2014? AND what is the predicted ratio of people with diabetes by 2050?
4% and 1/3
Describe the complex between short mothers and placenta size in regards to heart disease.
Smaller placentas in shorter mother resulted in increase risk of heart disease for the child. No relationship found in taller mothers.
What fetal periods of development are the most sensitive to nutrition, stress and low oxygen?
Embryonic and late fetal periods of development.
Hemodynamics
The study of the movement of blood through the circulatory system.
Share what supersized you!
Discuss
What does the birth weight effect graph look like? Please Draw
high risk at low weight and high weight
What gene is responsible for health of the placenta resulting in fetal heart death, if absent?
HOXA13
List three "Second hits" that determine disease outcome in a persons adults life, not birth weight?
Diet, Infection, Social ques, Exercise, stress, hormones, stress toxins...
Name one of the two hormones that suppress the proliferation of the heart cells in development.
Tri-iodo-thyronine (Thyroid Horomone) or Atrial Natriuretic Peptide
Explain the role of methylation of one gene in the hypoxia study.
Please because I don't understand it