What is HDx?
The next innovation to improve HD treatments for our patients by removing middle, large-middle molecules that is contributing to negative clinical manifestations in patients.
What is HDx.
The transport principle when solutes are carried through the membrane pores by ultrafiltration, which enables higher clearances of larger solutes.
What is Convection.
What is the leading cause of mortality in Hemodialysis patients?
Cardiovascular Disease
According to the Ariza study, after switching patients to HDx, annual hospitalization days were significantly reduced by how many days per patient year?
What is 1.5.
Light weight, smart, safe, reduced maintenance, and cost effective.
What is AK 98.
CleanCart cartridges make dialysis machine cleaning, ____, and disinfection simple, safe and efficient.
What is decalcification.
HDx Therapy targets the efficient removal of large-middle molecules: Which size of molecules are these?
What is >25-58k Da.
The Theranova dialyzer has a tight pore size distribution with a ____ sieving curve.
What is steep
Restless leg syndrome has been associated with __ and decreased __.
What is mortality and Survival.
According to the Blackowicz study, hospitalizations were ___% lower in patients treated with HDx therapy with Theranova compared with high-flux HD.
What is 45%.
AK 98, Theranova, Revaclear, Polyflux, Bicart cartridges.
What are HD products.
This cartridge is used for removing organic deposits, fats, and proteins from the dialysis machine fluid circuit.
What is CleanCart A (Sodium Carbonate).
Expanded Hemodialysis (HDx) is a dialysis treatment where __&__ are conveniently combined inside a hollow fiber dialysis, equipped with a HRO membrane defined as medium cut-off membrane.
What is Diffusion & Convection
What are the 4 principles that are unique to the Theranova membrane?
What is:
Higher permeability
Effective selectivity for larger proteins
Enhanced Internal Filtration
Retention of endotoxins
What is the impact of large-middle molecules on the patient? Name 3.
What is:
Inflammation
Endothelial dysfunction
CKD-Mineral bone disease
Cardiovascular disease
Infectious Diseases
Restless leg syndrome
Uremic pruritus
Poor recovery time
Which RCT study revealed that the Theranova MCO membrane improved patient-reported QoL outcomes in various physical domains and uremic pruritus' by efficient removal of large-middle molecules
What is the Lim study.
Reminder of low pump speed, disinfection, ultrafilter replacement.
What are smartsense alerts.
This cartridge is used for removing calcium and magnesium precipitation from the dialysis machine fluid circuit.
What is CleanCart C (Citric Acid).
The molecular weights of small-middle molecules are __.
What is 0.5-15k Da.
A reduced internal diameter of __micrometers maximize internal filtration inducing a higher TMP of 50 mmHg.
What is 180.
Daily Double
Accumulation of Free Light Chains can cause what?
What is Promotion of the pro-inflammatory state characteristic of patients with advanced kidney disease.
According to the Bolton study, when switching to HDx therapy with MCO membrane, patient reported recovery time showed statistically significant decrease from __ to __months.
What is 6 - 12.
Adequacy, KT/V, monthly labs.
What is Diascan.
CleanCart cartridges may result in ____% less space and ___% less weight for simpler storage.
What is 69 & 85.
Linked to chronic inflammation, cardiovascular disease, secondary immunodeficiency, erythropoietin resistance, and symptom burden.
What are Conventional/large-middle molecules
A unique principle of the medium cut-off membrane contributes to the retention of Albumin.
What is effective selectivity for larger proteins.
Uremic Pruritus has been associated with __% higher mortality risk, which appears to be mediated in large part through disturbances in sleep quality.
What is 17%.
Which study demonstrated that Theranova provides significant and superior removal of conventional/large middle molecules while retaining stable albumin levels?
What is the Weiner study.
Uses zero concentrate saves clients $139 / machine.
What is concentrate bypass mode.
CleanCart cartridges may result in roughly ___% annual savings per machine and minimized shipping costs.
What is 40.
Daily Double
Albumin loss with Theranova per 4-hour treatment.
What is 2-4 gm.
The medium cut-off membrane delivers higher permeability for small-middle, and large-middle molecules via __.
What is decreased nominal pore sizes.
Which molecule is associated with poor recovery time?
What is Interleukin-6 (IL-6)
HDx may be a cost-saving therapy with a per patient annual cost reduction of __ primarily driven by a decrease in all-cause patient hospitalization events.
What is $4,931. (Blackowicz Study)
Fluid divertor, U9000 ultrafilter.
What is Auto leak detection.
Which cartridge must be used in combination with the heat disinfection program of the corresponding dialysis machine?
What is CleanCart cartridges A & C.