Pharm and Genetics
Rando
Review
100
This is the diagnosis associated with MADH4 mutation.
Juvenile Polyposis 
100
This portion of the GCS is the best predictor of long-term outcomes in TBI patients.
Motor score POST resucitation
100
Excessive stoma output leads to this acid-base disturbance.
Non-anion-gap metabolic acidosis
Due to loss of HCO3- and compensatory increase in Cl- displacement into the extracellular space and Cl- reabsorption in the kidneys, this leads to hyperchloremic metabolic acidosis.
200
This is an antidote given for cyanide toxicity.
Antidotes include Sodium Nitrite (causes methemoglobin/hypotension), amyl nitrite (less commonly used now), hydroxocobalamin (first-line because it does not cause hypotension or methemoglobinemia), and sodium thiosulfate.
200
True or false:
Granulomas are associated with Crohn's disease
Crohn's: Cobblestone mucosa, noncaseating granulomas up to 50%, creeping fat, transmural/full-thicness inflammation
200
Patients with prolonged R Time on TEG need this.
300
This is how long methotrexate should be held prior to surgery
Not held at all.
Higher risk of flare/relapse than increased infection rates.
300
This is given to patients with coagulopathy and antithrombin III deficiency
FFP is given to restore heparin responsiveness
Heparin works by accelerating antithrombin's inhibition of thrombin and factor Xa several-thousand-fold, so when AT is depleted, heparin fails
400
This is the mechanism of action of both milrinone and cilostazol
Phosphodiesterase-3 inhibitor • decreases the rate of cAMP degradation, increasing cellular concentrations and improving myocardial contractility by increasing calcium influx into cells, and causing peripheral vasodilation in smooth muscle cells.
400
True or False:
The anabolic phase starts 6-8 days post op in an uncomplicated post-operative course
False
Immediate post op 1-3 days: catabolic aka adrenergic-corticoid phase = negative nitrogen balance due to neurohumoral changes associated with the stress response. Cortisol mobilizes amino acids for gluconeogenesis. Glucagon increases glucose levels. Increased Epinephrine mobilizes fatty acids and stimulates glucose metabolism into lactate; ADH and aldosterone increase Na and water retention.
Anabolic phase post op days 3-6 = positive nitrogen balance and an increase in the insulin-to-glucagon ratio. Decrease in cortisol, epi, ADH, and aldosterone.