What's up dox
A common side effect about doxorubicin that should be mentioned to patients is their bodily secretions potentially turning what color?
Red
What is the name of the disease that is described as being an asymptomatic form of of multiple myeloma? Patients with this disease are at a higher risk of progressing to multiple myeloma...
Smoldering myeloma
Myelosuppression is one of the most common warnings associated with chemotherapy. What two supplements can be used to reduce the chances of myelosuppression in patients on alimta?
folic acid and vitamin b12
Which two hematologic malignancies put a patient at higher risk for experiencing tumor lysis syndrome?
acute leukemia and high grade lymphomas
When the targeted AUC for carboplatin is greater than or equal to _____ it is classified as having high emetogenic risk, but if the target is less than that number the emetogenic risk is moderate.
4
One of the black box warnings for doxorubicin is related to the toxicity it can cause to which major organ in the body?
The heart
Similar to thalidomide, this drug used to treat patient’s with multiple myeloma has a REMs program due to it’s fetal toxicity risk...
lenalidomide
Vincristine and vinblastine are two drugs that should be only administered via a properly placed IV needle or catheter due to it having what kind of associated risk?
Extravasation risk
What rhyme can be used to describe the symptoms associated with hypercalcemia of malignancy?
bones, groans, moans, stones, and thrones
Dexamethasone is the preferred corticosteroid for antiemetic prophylaxis because its long half life allows for it to be dosed how many times a day?
Once
The mechanism of doxorubicin is the inhibition of DNA and RNA synthesis by intercalation between DNA base pairs and inhibiting which DNA enzyme?
Topoisomerase II
Some multiple myeloma patients undergo stem cell transplant, but prior to transplant they need to undergo this type of therapy using drugs like melphalan…
Conditioning therapy
What drug is used prior to infusion of irinotecan to prevent the immediate onset of diarrhea?
Atropine
For tumor lysis syndrome, certain drugs can be used prophylactically for hyperuricemia. Rasburicase works by converting uric acid into what more soluble molecule?
Allantoin
For patients who are on medications with a potential for low emetogenic risk, how many prophylactic antiemetic agents are preferred?
1
Due to toxicity risks associated with doxorubicin, it has an overall cumulative lifetime max dose of …?
550 mg/m2
Prior to starting daratumumab, patients should recieve a titer for what virus due to risk of reactivation?
HepB
What is the name of the dermatologic adverse effect associated with capecitabine and 5FU that can cause peeling, redness, blisters, and thick calluses?
Hand-Foot Syndrome
In patient’s with hypercalcemia of malignancy, what hormone related proteins do tumor cells release to increase that cause osteoblast to increase RANKL expression?
parathyroid hormone related proteins (PTHrP)
Which commonly used antiemetic can also be as an antipsychotic agent?
olanzapine (zyprexa)
Similar to Amphotericin B, doxorubicin comes in 2 different forms that aren’t interchangeable. Which of these forms has a more favorable toxicity profile?
Liposomal
What acronym can be used to help remember the features of multiple myeloma?
CRAB (calcium (high), renal failure, anemia, bone lesions)
While receiving rituximab infusions, some patients experience chills and shivers that can be managed with what agent?
Demerol
Which two musculoskeletal symptoms/signs can present in a patient with tumor lysis syndrome due to hypercalcemia?
Trousseau’s sign and Chvostek’s sign
Chemo induced nausea and vomiting can be broken down into 5 different categories. What is the name of the category that involves n/v prior to chemo administration that may be related to poor control during previous treatments?
Anticipatory