WBC Maturation
This is the earliest recognizable precursor in granulocyte development.
What is a myeloblast?
An increased number of immature neutrophils in circulation.
What is a shift to the left?
This leukemia is characterized by blasts and sudden onset.
What is acute leukemia?
This stain is positive in AML and detects peroxidase activity.
What is myeloperoxidase (MPO)?
Platelet count less than 150 × 10⁹/L.
What is thrombocytopenia?
This stage is known for primary (azurophilic) granules appearing.
What is a promyelocyte?
Seen in infections; includes toxic granulation, Dohle bodies, and vacuoles.
What are neutrophils?
This leukemia has slow onset and increased mature cells.
What is chronic leukemia?
This stain is also positive in AML and similar to MPO.
What is Sudan Black B?
Platelet count greater than 600 × 10⁹/L due to overproduction
What is primary thrombocytosis?
This stage marks the first time specific granules appear.
What is a myelocyte?
Rod-shaped inclusions seen in myeloblasts.
What are Auer Rods?
This MPN is associated with increased RBC production.
What is polycythemia vera (PV)?
This stain is positive in ALL.
What is PAS (Periodic acid-Schiff)?
This disorder involves deficiency of von Willebrand factor.
What is von Willebrand disease?
This stage shows indentation of the nucleus but no segmentation
What is a metamyelocyte?
Neutrophils with excessive nuclear lobes (>5).
What is hypersegmentation?
This leukemia is commonly associated with BCR-ABL (Philadelphia chromosome).
What is chronic myelogenous leukemia (CML)?
These CD markers are positive in AML.
What are CD13 and CD33?
This disorder involves missing GP IIb/IIIa receptors.
What is Glanzmann thrombasthenia?
This mature cell has a segmented nucleus and is most abundant in circulation
What is a segmented neutrophil?
A benign inherited disorder with hyposegmented neutrophils.
What is Pelger-Huët anomaly?
This MPN is characterized by excessive platelet production.
What is essential thrombocythemia (ET)?
These CD markers identify T-cell ALL.
What are CD3 and CD7?
This mutation makes Factor V resistant to Protein C.
What is Factor V Leiden?