Liver Issues

Presentation

100

In the early phases of the MASLD, the patient normally presents...

asymptomatic

200

What is the name of yellowing of the eyes

Scleral icterus

300

In the case of liver failure, are ALT and AST levels going to be elevated or not, and if so, why?

Can be normal to low. Liver functioning is greatly diminished or non-existent, so the liver is producing little to no AST or ALT. 

Labs and Imaging

100

What two enzymes do you want to test for to assess hepatocellular functioning?

ALT and AST

200

What is the ratio fo AST:ALT if the liver issue is primarily caused by alcohol use disorder

2:1

300

What is the name of the noninvasive estimate of liver scarring in HCV and HBV patients, to assess the need for biopsy 

FIB-4 index

Tx and Mx

100

What is the preferred diet that patients with MASLD should start?

Mediterranean Diet

200

What is the MOA of Rezdiffra

THR-beta agonist

300

What are the two fibrosis scores that patients must have in order to be eligible for treatment with Rezdiffra?

F2 and F3

Miscellaneous

100

After someone is diagnosed with diabetes, why do they need to be referred to an ophthalmologist?

To assess for diabetic retinopathy

200

A Fibroscan, which measures liver stiffness, is what type of imaging modality?

Transient Elastography

300

In the pathogenesis of MASLD, when visceral fat is gained, inflammation is caused via a release of which cytokines? (need to name 2 out of 3)

IL-1, IL-6, TNF