Basic Science
Clinical
200
These rare chemosensory epithelial cells are named for their distinctive tufted apical microvilli.
What are tuft cells?
200
Exposure to this pollutant is associated with worsened asthma symptoms, ED visits and low birth weight.
What is environmental tobacco smoke?
300
Along with IL-25 and IL-33, this epithelial-derived cytokine acts as an alarmin to activate ILC2s and amplify type 2 airway inflammation.
What is thymic stromal lymphopoietin (TSLP)?
300
This component of pulmonary function testing is commonly used as a surrogate marker for airway inflammation.
What is FENO?
400
This cytokine, produced by tuft cells, acts synergistically with cysteinyl leukotrienes to activate type 2 innate lymphoid cells (ILC2s) and initiate lung type 2 inflammation.
What is IL - 25?
400
IL-4 and IL-13 share a common receptor chain, which is the target for this biologic.
What is Dupilumab?
500
Along with IL-25 and IL-33, this epithelial-derived cytokine acts as an alarmin to activate type 2 innate lymphoid cells (ILC2s) and amplify type 2 airway inflammation.
What is TSLP?
500
This component of pulmonary function testing is used as the primary outcome measure in most FDA phase III asthma clinical trials
What is FEV1?
