Anatomy
What are 3 lymphatic organs?
Thymus, spleen, tonsils
What is the staging system used for Lymphomas?
Ann Arbor
What are the txt options for Lymphoma? (4)
Chemotherapy
Radiation
Stem Cell Transplant
Immunotherapy
What determines if a lymphoma is HL or NHL?
The presence of Reed Sternberg cells
What virus is a risk factor for lymphoma?
Epstein Barr
Where is Peyers patch found?
Small Intestines
What does “X” indicate in staging for lymphoma?
Bulky disease
What is the most common chemo used for HL?
ABVD
Which type of Lymphoma is more common- Hodgkins or Non- Hodgkins Lymphoma?
NHL
What are the most common sites of metastasis?
liver, bone marrow, or lungs
What does the right lymphatic duct drain?
Right arm, right side of the head, right thorax
What are B Symptoms?
What do "B" Symptoms indicate?
Fever
Night sweats
Unexplained weight loss of more than 10% of body weight
Worse prognosis
What 2 (or 3) txt fields are used to treat a TLI?
Mantle and Inverted Y (or mantle, PAN, and Pelvis fields)
What are the four subtypes of CHL?
Nodular sclerosis Hodgkin lymphoma
Lymphocyte-rich Hodgkin lymphoma
Lymphocyte-depleted Hodgkin lymphoma
Mixed cellularity Hodgkin lymphoma
Why do we want to treat with combined modalities?
Less toxicities from both.
What does the thoracic duct drain?
the left arm, left thorax, left side of the head and neck, lower extremities, pelvis and abdomen
A pt with 2 nodal areas , 1 in the right neck and 1 in the left chest by the carina with with no fevers, weight loss, or night sweats would be what stage?
II A
What type of RT fields are now used routinely?
Why are they used?
Involved fields.
To not induce secondary cancers.
What is the most common subtype of CHL?
What is the most common type of NHL?
Nodular sclerosis Hodgkin lymphoma
Diffuse large B-cell lymphomas (DLBCL)-
what is the common age range(s) for HL?
Bi-modal- late teens to thirties and again over 60
What are the parts of Waldeyer's ring?
The palatine tonsils, nasopharyngeal tonsil (adenoid) and lingual tonsil
What tests and procedures are used to diagnose lymphoma? (5)
Physical exam
Lymph node biopsy
Blood tests
Bone marrow biopsy
Imaging tests
What dose do we take lymphomas to?
Why these doses?
20-30 GY
Because they are very radiosensitive
What is the most common presenting symptom of lymphoma?
What are other symptoms? (gimme 3)
Painless swelling of lymph nodes in your neck, armpits or groin
Persistent fatigue
Fever
Night sweats
Shortness of breath
Unexplained weight loss
Itchy skin
What cells do lymphomas arise in?
Lymphocytes- B and T cells