Infectious Mononucleosis
Generalized lymphadenopathy is a common symptom of infectious mononucleosis. What lymph nodes are most likely affected?
What are posterior cervical and axillary lymph nodes?
This molecular alteration is associated with follicular lymphoma
What is t(14;18)?
Presentation at these ages is a poor prognostic factor
What are below age 2 or above age 10?
This acronym for the standard treatment of DLBCL may remind you of karate
What is R-CHOP?
This feature of the pattern of spread differentiates Hodgkin lymphoma from Non-Hodgkin lymphoma
What is predictability?
EBV virus binds this receptor, often found on mature B lymphocytes and follicular dendritic cells
What is CD21 (aka complement receptor 2)?
Name three features of lymph in FL that differentiate it from normal lymph
What are... Closely-packed follicles, less variability in follicular size, faint/absent mantle zones, no polarization into dark/light zones, absent tangible body macrophages, few mitoses noted
This gene translocation, seen in 25% of adult cases, has historically been a bad prognostic indicator
What is the Philadelphia chromosome, t (9;22)?
Dysregulation of this transcriptional repressor necessary for formation of normal germinal centers is found in some DLBCL cases.
What is BCL6
Involvement of 2 or more lymph node regions on the same side of the diaphragm is a feature of this stage of the Ann Arbor staging system
What is Stage II?
These antibodies are produced by infected B cells that react with horse or sheep RBCs
What are heterophiles antibodies?
The presence of these large cells with round/oval nuclei, and moderately basophilic cytoplasm, is used to grade follicular lymphoma
What are centroblasts?
Most blasts of lymphoid origin have this enzyme marker
What is TdT?
This variant of DLBCL is the most common, and comprises of irregularly-shaped nuclei with vesicular chromatin and small nucleoli
What is centroblastic variant?
This type of cell found in NSHL is defined by its large size, abundant cytoplasm, and empty space around the nucleus
What is a lacunar cell?
This mutation causes Duncan disease
What is SH2D1A?
This finding on immunohistochemistry differentiates follicular lymphoma from other lymphoproliferative processes and normal lymph nodes
What is BCL-2?
Up to 70% of all T-ALL have gain of function mutations in this gene that is essential for T-cell development
What is NOTCH1?
DLBCL, NOS is a clinically aggressive lymphoma composed of neoplastic B lymphocytes with this defining characteristic
What is nuclei that are at least twice the size of the nuclei of benign histiocytes or twice the size of small lymphocyte nuclei ?
Reed-Sternberg cells are derived from this type of cell and express these three immunophenotypic markers
What are GC or post-GC B cells and PAX5 (B cell TF), CD30, CD15 (in most cases)
There is thrombocytopenia in infectious mononucleosis due to this process
What is EBV-infected B cells secrete antibodies of many specificities, including anti-platelet antibodies?
Immunophenotyping of neoplastic cells in follicular lymphoma express these markers
What are CD19, CD20, CD10, BCL-6, and surface immunoglobulin?
These markers on immunophenotyping would determine the ALL is of T-cell lineage
What are CD1, CD2, CD5, and CD7?
This aggressive condition is associated with HHV8, causes profound immunosuppression and can grow in pleural, peritoneal, or pericardial effusions
What is primary effusion lymphoma?
This therapy has proved to be successful in treating relapsed or refractory disease
What are targeted anti-CD30 antibodies (i.e. brentuximab vedotin)