11.2
What are indicators that can be monitored for early detection?
Biomarkers
What is personal genomics?
The cheap, quick, accurate sequencing of an individual’s genome. Mostly uses whole genome sequencing, but sometimes uses whole exome sequencing as well.
What is pharmacogenomics?
customized medicine to reverse adverse effects)
What is another word for Ex vivo gene therapy and what process is it similar to?
What is the transplantation of a patient’s own tissue from one region of the body to another?
Autografting
Give an example of a biomarker.
proteins produced by diseased tissue, increased protein production as a result of abnormal tissue function, smart tattoos
What is the graph associated with genome wide association studies?
Manhattan Plot
What is the monoclonal antibody treatment of breast cancer?
What is used in in-vivo gene therapy to directly insert the DNA into a patient's cells.
A vector
What is xenotransplantation?
Transportation of organs from different species
Another word for gene chips.
Dna microarrays
What is the y-axis showing on the Manhattan Plot?
P-value, or statistical significance
Nanomedicine
Coated with molecules to help them bind to proteins and carbohydrates on the surface of cell targets, allowing them to be better, target specific therapeutic devices than conventional drugs
Give an alternate option instead of vectors in gene therapy.
Nanoparticles, Gene pills, Naked DNA, etc.
What are miniature organs produced from stem cells and grown in culture
Organoids
What is an antibody produced against one’s own, diseased cells?
Autoantibody
What is analyzing genes expressed by cells within a population, allowing researchers to differentiate genetic variations between cells?
Chemotherapy less painful, identification of breast cancer genes
What is the process of designing an RNA molecule that is a complementary base pair to the mRNA you want to inhibit, blocking it from being translated (aka RNA/gene silencing)
Antisense RNA technology
What is the development stage of an embryo in between 3-5 days into it called?
What does allele-specific oligonucleotide (ASO) analysis detect?
SNPs
What is the difference between diagnostic and prognostic?
diagnostic identifies a current problem or disease, while prognostic predicts its future course, outcome, and your chances of recovery
Pharmacogenomic treatment for chronic myelogenous leukemia.
Gleevec
What are DNA-editing nucleases that can be engineered to target specific DNA sequences? They can edit out and replace targeted defective genes.
Zinc Finger Nucleases
Name one place where human embryonic stem cells can be derived from.
Blastocysts, IVF created embryos