500
"I have almost forgot the taste of fears./The time has been my senses would have cooled/To hear a night-shreik, and my fell of hair/Would have at a dismal treatise rouse and stir/As life were in't./I have supped full with horrors/Direness, familar to my slaughterous thoughts,/Cannot at once start me."
This is said by Macbeth after Lady Macbeth screams as she kills herself. He is saying that he has no more emotions and cannot be frightened by a womans scream. He has lost his emotions and human qualities.