Digimon
TMNT
History
Transformers
Pokemon
100

Mascot of the Digimon franchise

Agumon

100

Leader of the foot clan

Shredder

100

How many Spartans died at Thermopylae?

300

100

Leader of the Autobots

Optimus Prime

100

My favorite Pokemon

Blastoise (I like turtles)

200

Created by the control spires

BlackWarGreymon

200

Name of the mutagen that transformed the turtles

The ooze
200

Emperor of the Franks

Charlemagne

200

Human protagonist of Transformers (2007)

Sam Witwicky

200

150/151

Mewtwo

300

Main Digimon of the newest game, Digimon Story: Time Stranger

Aegiomon, Aegiochusmon or Jupitermon

300

Warthog and Rhinoceros mutants

Beebop and Rocksteady

300

Discoverer of the Americas

Leif Erikson (Bonus points is you said the natives)

300

What company makes Transformers comics?

IDW

300

Pushed continents around

Regigigas

400

Three main types of Digimon

Data, Virus, Vaccine

400

Trained the Ninja Turtles 

Master Splinter

400

Longest reigning monarch in history

Louis XIV

400

Is The Cube from Transformers (2007) just a plot device?

Yes.

400

Region based off of Hawaii

Alola region

500

Two Digimon that combine to form Omnimon

WarGreymon and MetalGarurumon
500

Main human friend of the Ninja Turtles

April O'Neal

500

Watergate scandal 

Richard Nixon

500

Creator of the Transformers in the cannon

Primus

500

How many mega Pokemon are there?

80