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These are the advantages and disadvantages to using Markov's, Chernoff's, and Chebyshev's inequalities.
What are:
1) Markov's is simple but only works for non-negative random variables.
2) Chebyshev's works for negative rvs as well, but the variance must be known.
3) Chernoff's requires computation of the MGF, but once this is known, you can optimize t to get a tighter bound.