Clinical Trials/Efficacy
Across the 2 studies, which doses of Rexulti caused a greater reduction in MADRS total score from placebo?
What are 2mg and 3mg?
What adverse reaction occurred at the greatest % for Rexulti 3mg?
What is akathisia?
What is the maximum recommended dosage of Vraylar as an adjunctive treatment of MDD?
What is 3mg?
Late-occurring adverse reactions is included in the warnings and precautions for which of the atypical antipsychotics?
What is Vraylar?
In study 10, which dose of Vraylar was proven to be statistically significant from placebo?
What is 1.5mg?
What was the most common adverse reaction leading to discontinuation of Vraylar as an adjunctive treatment in clinical studies of patients with MDD?
What is akathisia?
What is the max recommended daily dose of Rexulti?
What is 3mg?
Name one thing (aside from hypersensitivity to Auvelity) that Auvelity is contraindicated with.
• Seizure disorder.
• Current or prior diagnosis of bulimia or anorexia nervosa.
• Abrupt discontinuation of alcohol, benzodiazepines, barbiturates, and antiepileptic drugs.
• Use with an MAOI or within 14 days of stopping treatment with AUVELITY. Do not use AUVELITY within 14 days of discontinuing an MAOI.
• Known hypersensitivity to bupropion, dextromethorphan, or other components of AUVELITY.
In Study 1, the difference between Auvelity and placebo in the change from baseline in total MADRS score was determined to be statistically significant as early as which weeks?
What are weeks 1 and 2?
What was the most adverse effect of Auvelity that lead to discontinuation?
What is anxiety (2%)?
On which day can the dose of Vraylar be increased (according to response and tolerability in clinical trials)?
What is day 15?
When was the first generic of Rexulti made available?
What is January 2025?
As early as which week in study 10 was Vraylar proven to be statistically significant from placebo?
What is week 2?
In clinical trials of patients with MDD, what percentage of patients treated with Rexulti as an adjunctive therapy discontinued treatment due to adverse events vs placebo?
What is 3%
What are the recommended starting doses of Rexulti for AMDD in adults?
What is 0.5mg or 1mg?
Auvelity is patented for the treatment of MDD until which year?
What is 2034?