Antibody Antics
In lupus, low levels of these complement proteins often accompany disease flares
What are C3, C4?
This “morning stiffness > 1 hour” is classically seen in this arthritis
What is Rheumatoid Arthritis?
This viral infection can present as symmetric arthritis and sometimes mimic RA
What is Parvo-B19 virus?
This molecule is inhibited by methotrexate
What is dihydrofolate reductase?
The triad of arthritis, conjunctivitis, and urethritis defines this syndrome.
What is Reactive Arthritis?
The ANCA subtype most strongly associated with microscopic polyangiitis
What is MPO-ANCA, P-ANCA
This medium-vessel vasculitis can spare the lungs yet involve renal ischemia, neuropathy, and mesenteric symptoms
What is polyarteritis nodosum?
This dermatologic condition is associated with arthritis mutilans.
What is psoriasis?
This JAK inhibitor carries a warning for thromboembolic risk
What is tofacitinib?
This syndrome is characterized by fever, rash, arthritis, and very high ferritin in adults.
What is adult-onset Still’s disease?
Anti–RNA polymerase III antibodies in systemic sclerosis are associated with increased risk of this complication
What is scleroderma renal crisis?
In eosinophilic granulomatosis with polyangiitis, which organ system most often drives mortality?
What is the heart?
This musculoskeletal complication is classically seen in hemochromatosis
What is MCP joint arthropathy (“iron fist” arthritis)?
This RA drug carries a boxed warning for GI perforation.
What is tocilizumab?
This autoinflammatory disease features cold-induced urticaria, deafness, and risk of amyloidosis.
What is Muckle-Wells syndrome?
Anti–Jo-1 is one example of this group of antibodies in idiopathic inflammatory myopathy
What are antisynthetase antibodies?
This positive skin test is usually seen in a vasculitis associated with oral ulcers, genital ulcers, uveitis.
What is pathergy test?
Which endocrine disorder can mimic proximal muscle weakness of polymyositis?
What is hypothyroidism?
Which urate-lowering agent increases risk of cardiovascular death compared to allopurinol?
What is febuxostat?
Which enzyme defect (in the cytolytic pathway) predisposes to macrophage activation syndrome in Still’s disease?
What is perforin (PRF1) deficiency?
In overlap syndromes, presence of anti–U3 RNP (fibrillarin) is most strongly associated with this organ manifestation
What is pulmonary hypertension (+/- cardiac disease)?
This ANCA-negative small-vessel vasculitis presents with recurrent pulmonary hemorrhage and rapidly progressive glomerulonephritis is mediated by which antibodies?
What are anti–GBM antibodies?
Palindromic rheumatism is strongly associated with this antibody.
What is anti-CCP?
This biologic targeting IL-12/23 has been associated with a paradoxical induction of arthritis in patients treated for psoriasis.
What is ustekinumab? (stelara)
This extremely rare syndrome combines adult-onset progressive muscle weakness, dysphagia, and inflammatory myopathy with a high risk of cardiac involvement, often mimicking polymyositis but with poor response to standard immunosuppression.
What is necrotizing autoimmune myopathy (NAM)?