Truth Be Mold
This dimorphic fungi transitions into specialized spherules that eventually release endospores
What is Coccidioides?
Temperatures are often below 20ºC in Canada to prevent P. falciparum from completing its growth cycle
Why is malaria not endemic in Canada?
Most common arbovirus in the world
What is dengue virus?
Mosquitos with soft bites that can spread flaviviridae
What are Aedes mosquitos?
They inhibit ERG11 to block ergosterol production
What are azoles?
Silver staining reveal thick double-walled yeast cells with no macrophage uptake
What histopathological evidence indicates blastomycosis?
One of the most diagnosed parasites in Canada, with ~40% reported cases from travellers of countries with poor sanitation practices
What is Giardia lamblia?
The viral life cycle occurring between domestic animals and insect vectors and the one between wild animals and insect vectors
What is a rural (epizootic) cycle and what is a sylvatic (enzootic) life cycle?
Over 25 million people in Africa live with this infection, although incidence rates are decreasing globally due to more diagnostic testing and improved treatment
What is HIV/AIDS?
They inhibit β-glucan synthase to destabilize the cell wall
What are echinocandins?
Patient presenting with flu-like symptoms, caseating granulomas, and new apical pulmonary lesions likely has which dimorphic fungi infection
What is chronic histoplasmosis?
Reason 60% of E. coli isolates in Russia tested positive for fluoroquinolone-resistant E. coli compared to 21% in Canada.
What is the example given in the module for the consequences of OTC antibiotic availability?
The body launches an ineffective immune response using a primary infection serotype
What causes a secondary dengue infection?
What is HCV (hepatitis C)?
Acyclovir, the DNA synthase inhibitor
How do you treat HSV?
A patient recently admitted for osteoarticular infections after refusing to be seen for a fever and cutaneous lesions, would most likely be suffering from this dimorphic fungi infection
What is Blastomycosis?
Canadian immigrants from tropical and subtropical regions may carry this parasite
What is S. stercoralis?
This arbovirus can be transmitted sexually from person to person
Why is Zika virus?
A hobbyist cavediver from Ohio is at risk of this disease
What is histoplasmosis?
It inhibits microtubule aggregation to inhibit the structural integrity of fungal cells
What is griseofulvin?
Shows a downy white colony as its macroscopic growth habit
What are the macroscopic growth habits the form of Coccidioides past 24ºC?
Medical services in India, Israel, Greece, or the US increase exposure to this type of organism
What are carbapenem-resistant organisms?
The mechanism in which West Nile Virus crosses the blood-brain barrier by disrupting endothelial cell junctions
What is the matrix metalloproteinase mechanism?
(TNF secretion can increase endothelial cell permeability too)
This endemic virus shows that what happens in Las Vegas does not always stay in Vegas
This polyene is used in immunocompromised patients with CNS involvement to ensure blood-brain barrier penetration
What is liposomal amphotericin B?