Antibiotics
The mitochondria of eukaryotic cells also have 70S ribosomes
Stopped or dysfunctional protein synthesis leads to growth arrest or death
What is Targeting Protein Synthesis?
Eukaryote, Prokaryote, Bacteria, Fungus, Protozoa, etc.
What are Classifications of Microorganisms?
The manner in which a pathogen enters a susceptible host
What is portal of entry?
Favorite movie
What is Good Will Hunting?
Inhibition of the cell wall
bacteria cell wall contains peptidoglycan
Antimicrobials that interfere with the synthesis of cell wall do not interfere with eukaryotic cells
High therapeutic index
What is Targeting Cell Wall Synthesis?
Surface layers are envelope
Cytoplasmic membrane, cell wall, capsule, cytoplasm, nucleoid.
What are Prokaryotic Cell Structures?
The place where the organism leaves the reservoir
What is portal of exit?
Favorite Color
What is my dark green?
Fluoroquinolones:
Interferes with DNA replication
Inhibit the enzymes involved in bacterial DNA synthesis in mRNAs and DNA replication
Rifamycins:
Target prokaryotic RNA polymerase initiation
Stops mRNA and therefore protein production
What is Targeting Nucleic Acid Synthesis?
Membrane bound nucleus, mitochondria, vacuole, endoplasmic reticulum, golgi apparatus, cytoplasm, nucleus (membrane bound), lysosome, ribosome, cell membrane
What is Eukaryotic Cell Structure?
Middle Name
What is Maria?
Interference with cell membrane integrity
Few drugs damage cell membrane
Binds membrane of gram negative cells
Alters permeability
What is Targeting Cell Membrane Integrity?
Permeability barrier, transport, cell to cell communication
Phospholipid bilayer embedded with proteins, sugars, cholesterols
Hydrophobic tails face in; hydrophilic head face out
Embedded proteins
Selective gates and transporters
Receptor, Sensors
Bind specific ligand
Important in cell
communication
What is the function and structure of the cell membrane?
My birthday
What is July 24 2002?
Drugs target enzymes used for folic acid synthesis in bacteria
E.g. Sulfonamides
What is Targeting Metabolic Pathways?
Has higher water potential than that of the cell so water will enter the cell from a region of higher water potential to lower water potential.
External solution that has a high solute concentration and low water concentration so the net movement of water will be out of the cell into the solution
What is the direction of water flow in a hypotonic/hypertonic solution?
Who is RYANNNN