Week 1
Credit if correct
Draw where the native state is on an energy landscape
Credit for correctness
What kind of protein is hemoglobin?
A globin
What is the deltaG for an endothermic reaction?
Positive
What IMF exists in every molecule?
London Dispersion Forces (LDFs)
What functional groups does each amino acid contain?
An amino group and a carboxylic acid
What is the rough formula for Keq?
[P]/[R]
What does a catalyst do to an energy diagram?
Decreases peak (Ea)
How many ionizable groups are there in Tyrosine?
3
What are the IMFs in CH3OH? Rank them from weakest to strongest
LDFs < dipole-dipole < h-bonding
If the pKa of an acid was low, what is the relative strength of that acid?
High strength
If a reaction had a deltaG = -67.3 kJ, another reaction had a deltaG = 36.3 kJ, and they were coupled, what is the overall deltaG?
deltaG = -31.0 kJ; spontaneous
What is the Kd in a ligand binding curve?
The pressure or concentration of substrate when a protein is half its maximum saturation
What is the ratio of base to acid in acetic acid with a pH of 8.9 and a pKa of 4.76?
13803.84
What is the name of the principle that systems adjust for when out of equilibrium?
Draw the polypeptide H-E-L-P
Look at structure
Why isn't omega on a Ramachandron plot?
Its partial double bond characteristic due to resonance makes it rigid and unable to be at other angles.
What is positive cooperativity? Give an example.
The binding of a protein to a substrate induces more substrate to bind to the protein; hemoglobin
What is the definition of pI?
The pH at which the charge of a polypeptide is neutral.
What is the ratio of products to reactants if K > 1?
There are more products than reactants
What determines the solubility of a molecule?
The presence of many C-H bonds, polarity, etc.
Where would the hydrophobic effect lie on an energy landscape?
In the middle
What is the likely secondary structure of a Φ ≈ -57° and Ψ ≈ -47°?
b-pleated sheet
What is the the spontaneity of a reaction when deltaH<0 and deltaS<0?
Spontaneous at low T
What electronegative molecules participate in h-bonding?
Nitrogen, oxygen, and fluorine