Characterized by production of structurally abnormal hemoglobin variants
What are hemoglobinopathies
100
This disorder presents with target cells, bar shaped intracellular crystals in the rbc's and is less severe than cickle cell disease
What is Hemoglobin C disease
100
A typical finding in chronic leukemias at onset.
What is elevated leukocyte count
100
Alder-Reilly anomaly is an abnormality of this
What is mucopolysaccharide metabolism
100
The depth between the counting platform and the coverslip on a hemacytometer.
What is 0.10 mm.
200
The three most common variant hemoglobin proteins in hemoglobinopathies
What are HbS, HbC, and HbE
200
The expected M:E ratio of a patient with aplastic anemia
What is normal (4:1)
200
The expected LAP score of a Chronic Myelogenous Leukemia
What is low (<13)
200
The initial laboratory technique for the diagnosis of monoclonal gammopathies
What are serum and urine electrophoresis
200
The cause of a true high MCHC
What are spherocytes
300
Disorder that presents with intrinsic factor antibodies, low cobalimin, gastric achlorohydria, and megaloblastic maturation in the bone marrow.
What is Pernicious Anemia
300
The leukemia that presents with a positive periodic acid-Schiff (PAS) stain
What is lymphoblastic leukemia
300
The type of leukemia that has cells that are CD14 and CD33 positive, Sudan Black B positive, specific esterase positive, and nonspecific esterase positive.
What is myelomonocytic leukemia
300
The method principle based on interruption of an electrical current by cells.
What is impedence
400
cells that have membrane loss and red cell trapping in the splenic microcirculaion, normal MCHC, and increased osmotic fragility
What are spherocytes
400
The abnormal hemoglobin present with a 95% band in the hgb S position on a acetate electrophoresis and a negative solubility test.
What is hemoglobin D
400
Naphthol AS-D chloroacetate esterase (specific) is usually positive in ________ cells, and alpha-napthyl acetate esterase (nonspecific) is useful for identifying blast cells of _______ lineage.
What are granulocyte and monocyte lineages
400
The key diagnostic test for Hodgkin lymphoma
What is lymph node biopsy
400
Measured by side angle scatter in a laser based cell counting system
What is cytoplasmic granularity
500
Disorder in which cells have an increased permeability to Na, deficiency in skeletal proteins(spectrin), and have an altered morphology only in mature rbc's
What is hereditary elliptocytosis
500
A disorder that has a high affinity for binding complement, chronic intravascular hemolysis due to lack of membrane glycolipid, hemoglobinuria and sucrose hemolysis positive(Ham's acid serum test)
What is paroxysmal nocturnal hemoglobinuria(PNH)
500
A familial disorder featuring pseudo-Dohle bodies, thrombocytopenia and large platelets
What is May Hegglin anomaly
500
Acute erythroleukemia (FAB M6) is characterized by increases of these in the bone marrow and sometime peripheral blood.
What is erythroid precursors and myeloblasts
500
The expected number of platelets seen per oil immersion field on a patient with normal platelet numbers.