Neuro
Compulsive drug craving, seeking & use w/negative consequences.
Addiction
Cannabis & Pregnancy
FDA says "NO"
Methadone MOA?
Tricks the brain into thinking it’s still getting the abused drug
Naltrexone is an opioid _____________?
aNtagonist
Disulfiram should never be taken while
intoxicated
VTA ---> NA ---> PFC
Reward Pathway
Misconception a/w MAT:
Substitutes one drug for another.
Methadone is a _________ that____________ effects of opioids while ____________withdrawal sx.
Methadone is a mu-opioid receptor that blocks effects of opioids while suppressing withdrawal sx
Methadone is an opioid ______________?
Agonist
12 hours after drinking alcohol.
Disulfiram should never be taken while intoxicated and it should not be taken for at least 12 hours after drinking alcohol.
"Nucleus Accumbens" AKA?
AKA "Ventral Striatum"
MAT medications work by?
Relieving withdrawal sx & psychological cravings
Buprenorphine is a _______ ______ of ___opioid receptors.
Buprenorphine is a partial agonist of mu opioid receptors.
Buprenorphine is a ___________ _____________ ___________ ?
Partial agonist of mu-opioid receptors.
“Artificial Alcohol”
Acamprosate
Mediated by dopamine pathways:
Positive rewards of reinforcement (disinhibition, euphoric mood, and anxiety reduction)
3 Opioid Dependency Medications?
Methadone, Buprenorphine, and Naltrexone
Like methadone, buprenorphine __________ & ___________ cravings for the abused drug.
Like methadone, buprenorphine suppresses & reduces cravings for the abused drug.
Naltrexone + drug use =
Fruitless, will not get high
Rx for people in recovery & stopped drinking
Acamprosate
Mediated by GABA pathways:
Negative rewards are aversive, such as increased anxiety and dysphoria.
Length MAT can be safely used?
Months, years, several years, or even a lifetime
Suboxone is
buprenorphine/naloxone
Naloxone
Antagonist
Naltrexone & ETOH recovery?
Blocks euphoria & feelings of intoxication