Medication Transfer
Safe vs. Unsafe
Resources
Alcohol
Caffeine, Nicotine & Tobacco
100

This property means a drug is less likely to cross into breastmilk because it binds to maternal proteins.

What is protein binding?

100

Brand name for the generic drug sertraline.

What is Zoloft?

100

This book is a “gold standard” for drug safety in lactation.

What is Hale’s Medications & Mothers’ Milk?

100

In general, this is the time it takes to clear one standard alcoholic beverage.

What is 2 hours?

100

Caffeine peaks in breast milk this many hours after maternal consumption.

What is 1–2 hours?

200

A drug’s ____-solubility increases its likelihood of transferring into milk.

What is lipid solubility?

200

This over-the-counter pain reliever is considered safe for breastfeeding and is widely recommended.

What is acetaminophen? OR

What is ibuprofen? 


200

This free online database is hosted by the U.S. National Library of Medicine.

What is LactMed?

200

Alcohol inhibits this hormone, which is essential for milk ejection.

What is oxytocin?

200

Nicotine reaches peak levels in breast milk within this time frame after smoking.

What is 30–60 minutes?

300

Medications with this type of half-life (short or long??) pose a higher exposure risk for infants.

What is a long half-life?

300

This sleep aid, also known as diphenhydramine, is considered unsafe for repeated use due to sedation and low milk production.

What is Benadryl?

300

These clinical guidelines are published by the Academy of Breastfeeding Medicine.

What are ABM Protocols?

300

Alcohol’s presence in breast milk is roughly equal to this bodily fluid concentration.

What is blood alcohol concentration?

300

Caffeine is considered safe in breastfeeding when intake is limited to this approximate daily amount.

What is 300 mg per day (about 2–3 cups of coffee)?

400

A medication must be bioavailable to affect the infant.

What is oral bioavailability?

400

Safest & most common antidepressant used while pregnant & breastfeeding. 

What is Sertraline?

400

This Texas Tech resource provides evidence-based medication advice.

What is the InfantRisk Center?

400

The metabolism of alcohol mainly occurs in this organ, explaining its time-dependent clearance.

What is the liver?

400

Nicotine has this approximate half-life in the body.

What is 2 hours?

500

Larger _______ size increases drug passage into milk.

What is molecular?

500

Drugs that should be avoided at all costs when breastfeeding.

What are chemotherapy drugs, radioactive iodine & certain immunosuppressants?

500

Number for a delightful, informative Free Lactation Warm-Line

888-791-MILK

500

Research shows that alcohol can alter this sensory property of breast milk, influencing infant feeding.

What is the smell and taste of milk?

500

E-cigarettes and vaping solutions often contain this harmful compound besides nicotine.

What are heavy metals (like lead and nickel)?