Localization
This organ is situated in the upper anterior thorax, just above the heart, and consists of numerous lobules, each clearly differentiated into the outer cortex and the inner medulla.
What is the thymus?
Beta2-microglobulin is a part of this important molecule.
What is MHC-I?
When enforced, this allows only one of the two copies of a gene to be expressed in a diploid cell.
What is allelic exclusion?
This process leads to clonal expansion and differentiation into effector T cells.
What is activation [by binding antigen]?
This term refers to developing T cells.
What are thymocytes?
This gene locus is integrated between the V and J segments of the alpha locus.
What is the delta locus?
This molecule is made up of a beta-chain and a surrogate alpha chain, and is first associated with the DN3 state.
What is a pre-T-cell-receptor?
This molecule is crucial for negative selection and opens up silenced chromatin to allow transcription of tissue specific antigens (TSA).
What is AIRE [AutoImmune REgulator]?
Strong binding to self-MHC and self-peptide leads to this process.
What is negative selection?
The term "double positive" refers to an immature T-cell expressing both of these molecules.
What are CD4 and CD8?
This percentage of developing thymocytes are positively selected, do not undergo apoptosis, and will eventually leave the thymus.
What is 2%-4%?
Signaling via this receptor commits a lymphocyte to the T-cell lineage.
What is Notch?
Daily Double!
The contestant who chose this tile writes down how many points they would like to wager. If you guess correctly, you get that many points. If you guess incorrectly, you lose that many points.
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Expression of a pre-TCR leads to cell proliferation and the arrest of this process.
What is VDJ[beta] rearrangement?
This phenomenon refers to the T-cell recognition of antigens requiring a complex consisting of an antigenic peptide and a self-MHC molecule.
What is MHC restriction?
Daily Double:
Mutations in Autoimmne Regulator lead to this condition.
What is Autoimmune PolyEndocrinopathy Candidiasis Ectodermal Dystrophy [APECED]?
Final Jeopardy -
All contestants write down a wager before the question is read. Then, all contestants answer on their own paper.
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Final Jeopardy -
A "double negative" cell who is also CD44- and CD25- is in this stage of development.
What is DN4?