General Transcription
What molecule is produced by transcription
mRNA
Where does Polymerase bind for highly transcribed genes?
TATA box
What controls the location of RNA Pol binding?
What type of molecule is typically a repressor
A Protein or small RNA
A complex of proteins that sense trouble is called a(n)
Inflamasome
Does an RNA molecule have an -OH group on the 2' carbon?
Yes
What is the region called that contains a TATA box?
Promoter
T or F: An enhancer promotes DNA binding
False: It increases gene expression.
What type of molecule is usually an enhancer?
A Protein
Regulation on a gene from a distance is called
Epigenetic Regulation
Protein Concentration is mostly controlled by?
Rate of Transcription
What is the name of a promoter that is found in about 70% of protein genes and is transcribed at a slow rate?
GpC islands
Do transcription factors have to be close to the binding location for RNA polymerases?
No
T or F: Activators and repressors are not usually tissue specific and are conserved.
False
What type of immune cell is activated from the NF-kB pathway?
B cells
What is the polymerase responsible for mRNA production, Pol I, Pol II or Pol III
Poly II
Does the RNA polymerase complex assembly all at once or sequentially?
Sequentially
T or F: Repressors and enhancers cannot share a gene.
False. The opposite is true most of the time.
What is a common repressor method involving chromatin?
Deacylation
What is a general term for a group of small, noncoding RNAs that are involved in all sorts of regulatory shenanigans?
ncRNAs
What molecule does Polymerase I produce?
Pre-RNA
The preinitiation complex contains a number of protein helpers. What is their general name.
Transcription factors
Cooperative binding of transcription factors are usually related proteins.
No, just the opposite.
The complex that creates a 'bridge' with transcription factors and is able to work with many different transcription factors at once is called the
Mediator complex
What is Rheumtoid arthritis (RA) thought to be caused by?
Alterations in the DNA methylation and histone activity of the cell