More Drugs!

Endocrine Drugs

100

Blocks TPO, can be used during first trimester

PTU

200

What drug is used to treat exophthalmos in graves disease?

Steroids

300

Name a hematologic side effect of methimazole

agranulocytosis and aplastic anemia

400

What drug treats SIADH and causes neurogenic DI

Demeclocycline

500

Give the mechanism of Cinacalcet

Sensitizes Ca2+ receptor (CaSR) in parathyroid gland to circulating Ca2+ --> decreasing PTH

Repro Drugs Female

100

Drug given to delay puberty and how is it administered?

Leuprolide; continuously

200

Antagonist at estrogen receptors in hypothalamus; treats infertility due to anovulation

Clomiphene

300

List 3 contraindications for combined estrogen and progesterone contraceptives

1. Smoker >35 y/o

2. CVD high risk

3. Migraines w/ aura

4. Breast cancer

5. Liver disease

400

What is the difference in mechanism of tamoxifen vs raloxifene (agonism vs antagonism)

Tamoxifen: antagonist at breast, agonist at bone and uterus

Raloxifene: antagonist at breast and uterus, agonist at bone

500

Mechanism of mifepristone vs mechanism of misoprostol

mifepristone: competitive inhibitor at progesterone receptors

Misoprostol: PGE1 agonist 

Repro Drugs Male

100

What drug has these adverse effects? :

headache, flushing, dyspepsia, cyanopia, hypotension while taking nitrates

PDE5 inhibitors

200

Tamsulosin mechansim

alpha1 antagonist selective for alpha 1A/D (prostate)

300

What enzyme does ketoconazole inhibit?

17 alpha hydroxylase/17,20 desmolase

400

Nonsteroidal competitive inhibitor at androgen receptors; treats prostate carcinoma

flutamide

500

Testosterone can be used to treat this dermatologic emergency (not repro related :-) )

Promotes burn recovery (stimulates anabolism)

GI Drugs

100

Agonist of u-opoid receptor, slows gut motility

Loperamide

200

What is first line for treating c diff?

Vancomycin oral (NOT metonidazole anymore)

300

What drug is used to treat a mild case of UC?

Severe case of UC? (6 or more fatty/bloody stools per day)

Sulfasalazine = mild

Infliximab = severe

400

Inhibts gastric and pancreatic lipase, decreases breakdown and absorption of dietary fats --> weight loss drug!

Orlistat

500

Name a drug that inhibits H1 receptors

Diphenhydramine, etc

Misc

100

What is the treatment for carcinoid tumors?

octreotide 

200

What 2 conditions do bromocriptine treat?

Prolactinoma and acromegaly

300

Treats endometriosis and hereditary angioedema, synthetic androgen that acts as partial agonist at androgen receptors

Danazol

400

List 3 drugs to treat thyroid storm

Propanolol (beta blockers)

PTU

Corticosteroids

Potassium iodide

500

What GI SPECIFIC drug increases risk of c diff?

PPIs