MOTOR Jeopardy

Olympics

100

The country that won the most medals at Tokyo 2020

What is USA?

200

This woman gymnast won the all-round gymnastic gold medal

Who is Suni Lee?

300

This American swimmer won 5 gold medals at Tokyo 2020

Caeleb Dressel?

400

Name two new sports that debuted at the Tokyo 2020 Olympics.

skateboarding, surfing, karate and sport climbing

500

This American track star was banned from the Tokyo 2020 Olympics for smoking weed

Who is Sha’Carri Richardson?

EGFR

100

What does EGFR stand for?

Epidermal growth factor receptor

200

What are two potential side effects from EGFR inhibitors?

Rash, diarrhea, dry skin, nausea

300

What percentage of non-small cell lung cancers have EGFR mutations? Be within 10% of the correct answer.

15%

400

Name three EGFR inhibitors

Erlotinib, afatinib, dacomitinib, osimertinib, gefitinib

500

What are two mechanisms of resistance we see to EGFR TKIs?

Acquired EGFR alterations, RET fusions, ALK fusions, histologic transformation

Mutations, mutations mutations

100

What are three mutations that we see in lung cancers?

EGFR, RET, ROS1, ALK, KRAS, BRAF, MET exon 14, NTRK

200

What is a liquid biopsy and what does it detect?

It detects tumor cfDNA in the blood and can detect lung cancer mutations

300

Name two treatments and the gene mutations that they target.

RET- selpercatinib

ROS1- crizotinib

ALK- alectinib

etc

400

Name an ALK inhibitor

alectinib, crizotinib, lorlatinib, ceritinib, brigatinib

500

Name a RET inhibitor

selpercatinib, pralsetinib

Celebrity couples

100

Who is Jennifer Lopez currently dating?

Ben Affleck

200

What is the name of Prince William's wife?

Kate Middleton

300

Which two judges on The Voice just got married?

Gwen Stefani and Blake Shelton

400

Name the SNL actor who is married to Scarlett Johansson

Colin Jost

500

Name three ex-boyfriends of Jennifer Anniston

Brad Pitt, Vince Vaughn, John Mayer, Bradley Cooper, Justin Theroux, John Mayer

Protocol numbers

100

Name the protocol number for osimertinib + bevacizumab

OR

Tell us what kind of drug bevacizumab is

16-033

VEGF inhibitor

200

What is the other name for U3-1402?

Or what was the protocol number for the phase 1 study?

Patritumab Deruxtecan

17-559

300

What is the protocol number for the Cullinan drug

or

What type of EGFR mutation does CLN-081 target?

19-471

EGFR exon 20 inhibitors

400

What patients are eligible for the ORCHARD study?

or

What are two cohorts of the ORCHARD study?

patients with acquired resistance to osimertinib

RET fusions, ALK fusions, MET amp, EGFR amp

500

On the shedders study, what are we looking for to see whether someone is eligible for randomization?

Detectable EGFR ctDNA on the Guardant test