Show:
Statin Strategy
TG Tactics
Gut & Liver Action
Next Gen Drugs
Clinical Safety Zone
100

Which statin is least dependent on CYP450 metabolism?

a. Simvastatin
b. Lovastatin
c. Atorvastatin
d. Pravastatin

D. PRAVASTATIN

100

Which fibrate has the highest risk of myopathy with statins?

a. Gemfibrozil
b. Bezafibrate
c. Ciprofibrate
d. Fenofibrate

A. GEMFIBROZIL

100

Which drug undergoes enterohepatic circulation?

a. Niacin
b. Ezetimibe
c. Fenofibrate
d. Rosuvastatin


B. EZETIMIBE

100

PCSK9 inhibitors belong to which drug class?

a. Enzyme inhibitors
b. Small molecules
c. Monoclonal antibodies
d. Prodrugs

C. Monoclonal antibodies

100

Which lipid drug is safest in pregnancy?

a. Statins
b. Niacin
c. Fibrates
d. Bile acid resins

D. Bile acid resins

200

Which effect best explains the LDL-lowering action of statins?

a. Decreased cholesterol absorption
b. Increased bile excretion
c. Increased LDL receptor expression
d. Increased HDL synthesis

C. INCREASED LDL RECEPTOR EXPRESSION

200

Niacin lowers triglycerides mainly by which mechanism?

a. Blocking NPC1L1
b. Inhibiting lipolysis
c. Increasing bile excretion
d. Blocking LDL receptors

B. INHIBITING LIPOLYSIS

200

Which bile acid resin is available in capsule form?

a. Colesevelam
b. Colestipol
c. Cholestyramine
d. Gemfibrozil

A. COLESEVELAM

200

PCSK9 inhibition results in which of the following?

a. Decreased LDL receptors
b. Increased LDL receptors
c. Increased TG synthesis
d. Increased bile secretion

B. Increased LDL receptors

200

Which lab test should be monitored routinely with statins?

a. ALT
b. Creatinine
c. Sodium
d. Potassium

A. ALT

300

Modified TRUE or FALSE

Rosuvastatin must always be taken at night for maximum effect.

FALSE

Long half-life allows anytime dosing.

300

Modified TRUE or FALSE

Fibrates primarily lower LDL cholesterol.

FALSE

Fibrates primarily lower triglycerides.

300

Modified TRUE or FALSE

Ezetimibe interferes with fat-soluble vitamin absorption.

False

It does not significantly affect vitamin absorption.

300

Modified TRUE or FALSE

PCSK9 inhibitors are given orally once daily.

FALSE

Given subcutaneously.

300

Modified TRUE or FALSE

Statins should be stopped immediately in all patients with mild muscle pain.

FALSE

Evaluate CK first before stopping.

400

Identify the metabolic complication that increases statin toxicity when combined with macrolides.

CYP3A4 inhibition

400

Identify the receptor activated by fibrates to increase fatty acid oxidation.

PPAR-α

400

Identify the drug class that increases conversion of cholesterol to bile acids.

BILE ACID-BINDING RESINS

400

Identify ONE approved PCSK9 inhibitor.

Alirocumab / Evolocumab

400

Identify the lipid drug contraindicated in gout.

NIACIN

500

Enumerate THREE indications for high-intensity statin therapy.

  • Established ASCVD

  • LDL ≥190 mg/dL

  • Diabetes with high risk

  • Post-MI patients

  • Familial hypercholesterolemia

500

Enumerate THREE adverse effects of fibrates.

  • Myopathy

  • Gallstones

  • GI upset

  • Prolonged PT

  • Elevated liver enzymes

500

Enumerate THREE drugs whose absorption is reduced by bile acid resins.

  • Warfarin

  • Digoxin

  • Thyroxine

  • Thiazides

  • Fat-soluble vitamins

500

Enumerate THREE situations where PCSK9 inhibitors are recommended.

 

  • Familial hypercholesterolemia

  • Statin intolerance

  • Persistent high LDL

  • Secondary prevention

  • Very high ASCVD risk

500

Enumerate THREE baseline assessments before starting lipid therapy.

  • Lipid profile

  • Liver enzymes

  • CK (if high risk)

  • Renal function

  • Fasting glucose