Path to roid rage
This is the principal glucocorticoid
What is cortisol?
Slide 6
This glucocorticoid drug is just cortisol
What is hydrocortisone?
Slide 18
This is the main overarching side effect of long-term oral therapy
What is iatrogenic cushing's syndrome?
Slide 5
This medication is most commonly associated with muscle side effects
What are statins?
Slide 18
This professor likes to solve rubix cubes in their spare time
Who is Dr. White?
This is the effect cortisol has on blood glucose and fatty acid levels in the blood
What is increase?
Slide 13
This is the maximum number of glucocorticoid injections a patient can have per year
What is 3-4?
Slide 21
This may result from abruptly stopping GC drugs after more than 2 weeks of therapy
What is adrenal insufficiency?
Abruptly stopping short term GC use (3-10 days) is fine
Slide 8
This is the main laboratory finding seen in Drug-induced myopathy
What is increased creatine kinase?
Slide 14
This professor was a long distance runner in high school
Who is Dr. Wirtu?
This is why there is a characteristic lag period for the effects of cortisol
What is the synthesis of new proteins?
Slide 8
This is the CYP enzyme that metabolizes glucocorticoid drugs
What is CYP3A4?
Slide 17
What is a tendon rupture?
Slide 7 of post session slideshow
This is the most severe, but least common clinical manifestation of drug-induced myopathy
What is rhabdomyolysis?
Slide 14
This professor has a Ph.D, M.D., M.S.C, and a M.B.A
Who is Dr. Ihentuge?
Cortisol inhibits this enzyme, preventing the release of arachidonic acid
What is Phospholipase A2?
Slide 14
This glucocorticoid has the highest anti-inflammatory potency
What is Dexamethasone?
Hydrocortisone - 1
Prednisone, prednisolone, methylprednisolone, triamcinolone - 4-5
Dexamethasone - 30
Slide 18
Rifampin, carbamazepine, and phenytoin all decrease GC drug levels due to this this interaction
What is the induction of CYP3A4?
Cimetidine, macrolide antibiotics, and ketoconazole are all CYP3A4 inhibitors and this increase drug levels
Slide 7 of post session slideshow
This is the most frequent type of myopathy seen in glucocorticoid induced myopathy
What is atrophic myopathy?
Slide 20
This professor played the viola back in the day
Who is Dr. Kin?
Cortisol inhibits cell-mediated immunologic functions, especially those dependent on these two immune cells
What are lymphocytes and tissue macrophages?
Slide 14
These two intermediate acting glucocorticoids have mineralocorticoid receptor activation
What are prednisone and prednisolone?
Slide 18
This is why glucocorticoid drugs can cause stomach pain, heartburn, peptic ulcers, and GI bleeding
What is the inhibition of prostaglandin secretion?
Slide 5 of post session slideshow
Although the exact mechanism of DIM from statins in not fully understood, these 2 effects of statins seem to be the most relevant
What are mitochondrial damage and decreased cholesterol in muscle cell membranes?
Slide 19
This professor worked as a stripper when they were younger
Who is Dr. Coppinger?