Pathopysiology
Multiple Myeloma involves neoplastic proliferation of _____ cells in the bone marrow.
Plasma
Corrected Ca is 11.2. What severity of hypercalcemia is this?
Mild
List 2 of the 3 treatment goals for MM
Disease control
Improve quality of life
Prolong survival
What drug class is Bortezomib?
Proteasome inhibitor
Monoclonal gammopathy refers to the excess production of what?
M protein
>/= 3 g/dL
Name 1 preferred regimen for patients eligible for autologous HCT.
Daratumumab/Lenalidomide/ Bortezomib/Dexamethasone (Dara-VRd)
OR
Isatuximab-irfc/Bortezomib/Lenalidomide/ Dexamethasone
What congenital defect is associated IMiDs?
Phocomelia
What 2 precursor conditions could eventually develop into active MM?
MGUS and Smoldering
The presence of which mutation is associated with improved survival?
t(11;14)
1st line maintenance therapy for transplant eligible and ineligible patients.
lenalidomide
Name a CD38 targeted MAB
Daratumumab
Isatuximab
List the 4 CRAB criteria for MM
Hypercalcemia, renal insufficiency, anemia, bone lesions
What is the most common M-protein found in Active MM?
IgG
What treatment involves the use of genetically modified T-cells?
CAR T-cell therapy
Which medication is only recommended for the t(11;14) mutation?
Venetoclax
Light chains found in the urine are known by this classic name.
Bence Jones Proteins
What are two laboratory methods to quantify M proteins?
electrophoresis and immunofixation
What is the minimum duration of bone modifying therapy in MM?
2 years (may be continued longer)
Which medication is used primarily for autologous HSCT?
Melphalan