Intro & Overview
Manifestations & Diagnosis
Management & Treatment
Special Interest
Misc.
100
Chronic diseases account for __ out of 10 of all yearly deaths in America and 60% of all yearly deaths worldwide.
7
100
What are the 3 psychological manifestations often seen in patients with Duchenne Muscular Dystrophy?
- Intellectual Disability
- Attention deficit/hyperactivity disorder
- Autism Spectrum Disorder
100
Give at least 2 examples of the type of therapy someone with MD might go through
- respiratory
- speech
- occupational
- physical
100
True or false: Gene Therapy trials have been proven to be successful.
True
100
Why does DMD mainly affect boys?
Because the dystrophin gene is attached on the X chromosome
200
In what year was Duchenne Muscular Dystrophy Discovered?
1860's
200
What is the main cause of death seen in Duchenne's Muscular Dystrophy patients?
cardio-respiratory failure
200
What type of medication might someone with MD be prescribed to manage their symptoms?
Corticosteroids
200
What is an example of assistive technology for people with MD?
- electric wheelchair
- voice activated lights
200
What is the name of the famous comedian that had diagnosed myotonic muscular dystrophy?
Gilbert Gottfried
300
What demographic does Duchenne Muscular Dystrophy mainly affect?
- Male
- 10-30's yrs old
- White
300
Historically, DMD has been known to present loss of ambulation between ages __-__ and death in the teens or __'s
7-13; 20
300
What are the two types of prevention of secondary symptoms of MD?
- medication
- surgery
300
What is the main purpose of assistive technology?
to improve someone with motor disabilities quality of life and enable them to live independently
300
What types of food should people with MD avoid?
processed food such as bread, pasta, and sugar
400
What are three disparities associated with MD?
- Black and hispanic men get diagnosed later in life than white men
- Marginalized treatment
- Low income can't afford treatment
400
Describe Gower's sign AND Meryons sign.
Gower' sign - when child uses hands to push off the floor/legs in order to stand upright.
Meryon's sign - When the child experiences looseness of muscles around the shoulders and tend to "slip through" when being picked up.
400
If your patient with MD is experiencing underlying health issues, what is 1 type of medication you might prescribe them?
- Glucocorticoids
- Anticonvulsants
- Immunosuppressants
- Beta blockers
400
Dystrophin is delivered to the body’s muscle cells via a single infusion of a _________.
Viral vector
400
How many types of MD are known?
8
500
What is the name of the man who discovered MD?
- Guillaume Benjamin Amand Duchenne
500
You are a doctor and suspect that your patient may have Duchenne Muscular Dystrophy, what are 3 abnormalities you are going to look for in the patients blood work?
- increased levels of creatine kinase [CK]
- amount of electrical activity in the muscles
- deletion/duplication in the DMD gene
500
What is an example of a surgery that someone with MD might undergo?
insertion of a pacemaker
500
What is the name of the protein gene therapy assists in producing?
Dystrophin
500
How old did the oldest person with MD live to be?
56