BASIC
What are the bundles that hold the muscle fibers called?
FASICLES
True or False: Each muscle fiber contains multiple nuclei.
TRUE
What is the transportation station of the muscle cell?
Sarcoplasmic Reticulum
During a muscle contraction, cross-bridges form between what two structures?
Actin & Myosin
What disease was Tom diagnosed with?
Duschenne Muscular Dystrophy
What are the types of cells found in muscles?
MYOCYTES
What is the outermost layer, surrounds entire muscle called?
Epimysium
What is the muscle fiber membrane?
Sarcolemma
What chemical helps to regenerate ATP?
Creatine Phosphate
What movement was used early in detection of Tom, after his mom was worried about his mobility?
Gowers manuever
What is the layer that separates & surrounds the fascicle?
PERIMYSIUM
What is the inner material surrounding the fibers?
Sarcoplasm
Cholinesterase is the enzyme that breaks down what?
Acetylcholine
What type of gene therapy did Tom use for treatment?
EXONDYS51
Provide the hierarchy how the muscle is organized:
Muscles - Fasicles - MyoFibers - MyoFibrils - Myofilaments
What layer surrounds each individual muscle fiber?
ENDOMYSIUM
Where are the contractile unit of a muscle located?
On each muscle fiber.
Place the following in order:
1. Acetylcholine crosses the gap at the neuromuscular junction
2. Actin & Myosin form cross bridges
3. Calcium is released into the sarcoplasm
4. myosin cross bridges pull actin filaments inward
1. Acetylcholine crosses the gap at the neuromuscular junction
3. Calcium is released into the sarcoplasm
4. myosin cross bridges pull actin filaments inward
2. Actin & Myosin form cross bridges
Explain what dystrophin is:
protein located between the sarcolemma & myofilaments, it is a cohesive protein that helps maintain the structure of the muscle fibers