Who am I?
This circulating myeloid cell can migrate into tissues and differentiate into macrophages.
Monocyte
A receptor which can recognize proteins - non Y shaped - opsonizing the the pathogens.
Complement receptor
During NETosis what is the main component what is released as a trap for pathogens?
The neutrophil's own DNA
This is the least abundant granulocyte in human peripheral blood (0-1%)
Basophil granulocyte
You want to develop a vaccine that efficiently activates naïve T cells. Which myeloid cell would you want to study?
Dendritic cell
This cell is found mainly in tissues rather than circulating in blood and plays a major role in immediate hypersensitivity reactions.
Mast cell.
It is a process during which the pathogen is taken up by a cell.
Phagocytosis
Which mediator is stored in mast-cell granules and is rapidly released during immediate hypersensitivity.
Histamine
It has the most lubulated nucleus.
Neutrophil granulocyte
A researcher wants to study a cell that retains antigen–antibody–complement complexes on its surface and helps B cells encounter antigen in a lymphoid follicle. Which cell should they study?
Follicular dendritic cell
I capture antigen in peripheral tissues and I migrate toward lymphoid tissue. I present antigen to T cells.
I am particularly important for initiating adaptive immune responses.
Dendritic cell
This antibody class is particularly important in mast-cell-mediated immediate hypersensitivity.
IgE
Which cell releases toxic granule proteins that are particularly effective against helminths?
Eosinophil
After centrifugation of the blood it gives approx 45% of the total volume.
Erythrocytes
A patient has an acute bacterial infection. Which cell would you expect to see in large numbers at the infected site?
Neutrophil granulocytes
I am particularly important in responses against helminths and in allergic inflammation. My granules contain proteins that can damage parasites.
Eosinophil granulocyte
All myeloid cells have this receptor which is capable of recognizing such molecules as lipopolisaccahrides, flagellin etc.
Pattern recognition receptor (PRR)
Which cell produces and releases a wide range of inflammatory mediators and can have either pro-inflammatory or tissue-repair functions depending on its activation state?
Macrophage
Before a sport competitions it is quite common to use this factor as a doping agent and it increases the number of RBCs.
EPO (erithropoetin)
A genetic mutation prevents neutrophils from efficiently producing reactive oxygen species. What aspect of their antimicrobial function would be affected?
Their ability to kill internalized microorganisms through oxidative mechanisms.
My mother is a hematopoetic stem cell and I have many kids: megakaryocyte, myeloblast, RBCs and mast cells.
Common myeloid progenitor
A cell can present the antigen to Helper T cells on this molecule.
MHC II
Name at least 2 compounds which can kill the pathogen in a phagolysosome.
Myeloperoxidase, ROS (reactive oxigen species), NADPH oxidase, Superoxide dismutase, Catalase
What is usually the ratio of monocytes in the blood in a healthy individual?
2-6 %
You have only one cell in your culture: large phagocytic cell, produces inflammatory cytokines, can present antigen, participates in tissue repair. What is your best guess? And what additional experiment would you perform to confirm it?
Macrophage
Flow cytometry, phagocytosis test (other functional test), cytokine test, transcriptomics