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All About Panels
Genes & Syndromes
Test Kit & Results
Cancer Sites
Conversion Message
100
The increase in cancer risk must be at least 3-fold higher than general population risk, the absolute risk of cancer must be approximately 5% or higher, and there must be significant data from multiple studies supporting cancer risk estimates.
What are the criteria used to label a cancer as High Risk?
100
A mutation in this BRCA gene is associated with higher risks for breast, second primary breast and ovarian cancers, but lower risks for pancreatic, male breast, prostate and melanoma.
What is BRCA1?
100
Green, red and gray.
What are the headline/banner colors on the myRisk Test Results and Management Tools?
100
The four new cancer sites being evaluated through myRisk.
What are prostate, melanoma, pancreatic and gastric?
100
This is the relative increase in sensitivity for myRisk.
What is 40-50%?
200
Mutations that are present at conception and typically occur in all cells of the body. These are inherited from one parent and can be passed on to children.
What are germline mutations?
200
This syndrome and gene mutation are associated with an increased risk for the diffuse form of gastric cancer and lobular breast cancer.
What are Hereditary Diffuse Gastric Cancer Syndrome and CDH1?
200
The color of the rubber top on the vacutainer in a myRisk blood test kit.
What is purple?
200
Of the three main types of ovarian tumors, this type is the most common and is more highly associated with inherited mutations.
What is epithelial ovarian cancer?
200
This is what caused a clinical dilemma among providers prior to the advent of hereditary cancer panels.
What is the uncertainty of receiving a negative test result?
300
The three components that make up the gene selection criteria.
What are cancer focus, clinically actionable and penetrance (absolute cancer risk of 5% or higher or cancer risk 2-3 fold or higher than the general population)?
300
A mutation in the STK11 gene is responsible for this syndrome.
What is Peutz-Jeghers Syndrome (PJS)?
300
Test result, personal and family history, personalized cancer risk chart, management recommendations and information for family.
What are the components of a myRisk Management Tool?
300
This type of cancer has a very good overall 5-year survival rate (99.2%), controversy exists over utility of screening for this cancer, and primary treatment for low-risk patients is usually surveillance with the intent to intervene with other treatment options if necessary.
What is prostate cancer?
300
It was presented at ASCO this year that 25% of patients with negative results and 78% of patients with positive results had management changes based on this.
What is the myRisk Management Tool?
400
The two driving forces in Myriad transitioning towards a hereditary cancer panel.
What are advances in technology and an improved understanding of overlap in phenotype?
400
This mutated gene or syndrome is associated with a female overall cancer risk of up to 100% and a male overall cancer risk of up to 73%.
What is TP53 or Li-Fraumeni Syndrome?
400
In the myRisk Management Tool, breast cancer risk based on family history is assessed using this online risk model to determine when women are estimated to have a greater than 20% risk for breast cancer.
What is the Claus model?
400
This type of cancer affects about 45,000 individuals every year, has the lowest 5-year survival rate (6%) out of all cancer sites included on myRisk, and there are currently no standard or routine screening tests.
What is pancreatic cancer?
400
This poster looked at 1,781 breast cancer patients and found that 32% of the pathogenic mutations detected were outside of BRCA1/2.
What is the Tung poster presented at ACMG in March 2014?
500
Of the 25 genes included on the panel, ____ have medical management guidelines directly related to them and the others have either a cancer risk that can be linked to society guidelines or at least one well designed study that illustrates an increase in risk over general population.
What is 15?
500
Mutations in CDKN2A(p16INK4a) and CDKN2A(p14ARF) put a person at an increased risk for these two cancers.
What are melanoma and pancreatic?
500
These are the two types of Genetic Test Results, whose headline banners are gray, that a provider could receive outside of a positive or negative.
What are positive for a recessive condition and findings that require special interpretation?
500
This type of cancer has a relatively poor prognosis, currently has no routine screening, and some of the risk factors include older age, male gender, being of Hispanic/Latino, African or Asian ethnicity, diet high in salt and smoked food, tobacco use, obesity, H.pylori, chronic gastritis, stomach lymphoma, etc.
What is gastric cancer?
500
Emerging data shows that this is the approximate percentage of positive mutations found outside of BRCA1/2 and/or Lynch syndrome genes.
What is 30%?