Nausea & Vomiting

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100

What are some patient related risk factors of CINV

Younger than 50 years old 

Female 

Hx of motion sickness 

Hx of N/V during pregnancy 

Poor Control of N/V in previous chemo cycle 

200

What is a positive risk factor of CINV

hx of chronic alcohol 

300

what is are some treatment specific risk factors of CINV?

Emetogenicity of drug 

Dose 

Infusion rate, cycle, and time of infusion 

Radiation therapy --> large areas, more areas of body, and more frequent 

400

Match the area of radiation treated with the risk of CINV (High Risk, Moderate Risk, Low Risk, Minimal Risk)  

A. Arms

B. Chest or Pelvis

C. Whole body

D. Upper Abdomen 

E. Head & neck 

F. Brain & Spine

G. Breast

H. Legs 

High Risk - C

Moderate Risk - D F 

Low Risk - B E 

Minimal Risk-  A G H 

500

Breakthrough CINV

Nausea and/or vomiting that occurs within 5 days post chemo despite optimal anti-emetic regimen used that requires rescue therapy with other antiemetics

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100

what are the side effects of 5-HT3 receptor antagonist? 

HA

Constipation

QT prolongation

200

What are the side effects of NK-1 Receptor Antagonist? 

Diarrhea 

Fatigue 

Weakness 

Hiccups

300

What nausea med can be given as a patch?

Granisteron

400

What NK-1 antagonist is not a CYP3A4 inhibitor? and what is it instead? 

Rolapitant; CYP2D6

500

Label if the med is PO or IV

- Aprepitant 

- Aprepitant Emulsion 

- Neturpitant + Palnosteron 

- Fosneturpitant + Palnosteron 

- Rolapitant 

- Fosaprepitant

- Aprepitant -PO 

- Aprepitant Emulsion -IV

- Neturpitant + Palnosteron -PO

- Fosneturpitant + Palnosteron -IV

- Rolapitant -PO

- Fosaprepitant -IV

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100

What are the side effects of the dopamine antagonist?

- sedation 

- lethargy 

- acute EPS

200

What medication has a BBW for tardive dyskinesia with long term use 

Metoclopramide

300

What medication can be give IM but can be give PO to reduce the risk of extravasation? 

Promethazine

400

What dopamine antagonist has a BBW for QT prolongation?

Droperdiol

500

What side effects does olanzapine cause? 

-Sedation 

-Dry mouth 

-Dizziness

-Postural Hypotension 

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100

What medication is reserved for highly emeticogenic regimens? 

Olanzapine

200

What are the side effects of lorazepam?

What formulations are available? 

Sedation 

Short-term memory loss

IV/SL/PO

300

What is side effect can occur if doronabiol is used chronically? 

Cannabinoid hyperemesis syndrome

400

What medication classes are used for acute CINV

-5HT3

-Corticosteroids

-Olanzapine

-NK1 antagonist

500

what medication classes are used for delayed CNIV

-Corticosteroids

-Olanzapine

-NK1 antagonist with palonosteron

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100

What medication classes are used breakthrough CINV

Dopamine antagonsit 

Weed

200

What medication classes are used for refractory CINV

Olanzapine 

Weed

300

What medication is used for anticipatory CINV

Lorazepam

400

Why can palonsteron be used for delayed CINV?

Long half-life (40 hours) 

500

Dopamine antagonist are effective for mild/moderate CINV. True or False 

True