Self-Titled
Regional at Best
Keep It Positive
Keeping up with the Kids
Not Stirred
100

This is the first disease that was screened for in newborns.

Phenylketonuria

100

T/F. NBS is standardized across the United States

False. Many states have a variety of tests that are performed.

100

T/F False positives are more likely than a true positive.

True. For some diseases 50 times more likely.

100

This Presbyterian pastor created a children's show where they invited them into his neighborhood, both real and make believe

Fred Rogers (Mr. Roger's Neighborhood)

100

This 1994 film is based on Shakespeare's Play "Hamlet"

The Lion King

200

T/F. Newborn screening tests for chromosomal abnormalities like Trisomy 13, 18, 21, Turner's

F. Non-invasive pre-natal testing or karotype must be performed for these disorders

200
Newborn screening is mandatory for all Virginia babies

F, exemptions for religious reasons

200

You as a PCP are called by the state for a positive screening on a baby you have not seen yet, what do you ask on the phone call?

Demographic information (just in case you don't actually have this child's stuff), the result that is abnormal, how abnormal is it, recommendations on follow up testing.

200

This Dr. helped to re-coin the phrase "If I had a nickel for everytime x happened" from "I'd be rich" to "I'd have two nickels, but it's weird that it happened twice right?"

Dr. Doofenshmirtz

200

This 2013 film is a novel take in the zombie genre modeled after Shakespeare's "Romeo and Juliet"

Warm Bodies

300

These are the risks of NBS (4)

• False-negative screening potentially providing a false sense of security

• False-positive results lead to parental anxiety and additional testing and treatment

• Revelation of misattributed paternity through genetic tests

• Allocation of limited financial and personal resources

300

Virginia Screens for this number of disorders on it's NBS (+/- 4)

35

300

A previously fairly sick NICU baby who just finished a NEC treatment course of 10 days has a NBS positive for methylmalonic aciduria. Your next steps are...

Repeat after off TPN

300

Name the 4 main characters in the hit children's show "Bluey"

Bluey, Bingo, Bandit, Chilli

300

This 1999 comedy staring Julia Stiles and Heath Ledger is a remake of the Shakespearean play "The Taming of the Shrew"

10 Things I Hate About You
400

This is the mechanism by which NBS is performed (think chemistry)

Tandem Mass Spectrometry (MS/MS). It utilizes two mass analyzers separated by a collision chamber, enabling laboratories to rapidly screen samples. Samples are broken down into progressively smaller fragments; these are sequentially sorted, weighed, and plotted on a histogram. The technology enables us to screen for disorders of fatty acid oxidation and organic acidemias in a matter of minutes. The additional benefit of this technology is improved sensitivity while still preserving low false-positive rates.

400

What genetic centers are involved in helping physicians interpret and order further testing for Virginia?

CHKD (Dr. Basinger), UVA, VCU, Children's National (D.C)

400

A worried parent comes into your office requesting help interpreting a whole-genome sequence test that they ordered to be done for their child who they are worried gets sick more often that others. They are worried about a variant on their child's test and want to know what that means. Discuss the risks/benefits of WGS.

WGS is much more broad than NBS, however you can have paternity discovering, variants of unknown significance, discovery of pathologic variants that the family/provider was not looking for.

400

Name the 3 main characters of Spidey and His Amazing Friends

Ghost Spider, Miles Morales, Spidey

400

This early 2000's movie starring Amanda Bynes as a soccer player is a remake of the Shakespearean Play "Twelfth Night"

She's The Man

500

These are the criteria for a test being included in NBS. (8)

• The disorder should pose an important health problem

• The natural history of the disorder should be well understood

• The disorder should be recognized at a latent or early symptomatic stage

• The test should be accurate, safe, reliable, inexpensive, and simple to administer

• The treatment should be effective with evidence of improved outcome with early treatment

• The program should be clinically, ethically, and socially acceptable

• There must be a system in place to confirm the disorder

• Follow-up care must be available to affected infants

500

Name 10 diseases screened for in Virginia

Argininosuccinic Aciduria

Citrullinemia, Type I

Classic Phenylketonuria

Homocystinuria

Maple Syrup Urine Disease

Tyrosinemia, Type I

Adrenoleukodystrophy

Carnitine Uptake Defect

Long-Chain L-3 Hydroxyacyl-CoA Dehydrogenase Deficiency

Medium-Chain Acyl-CoA Dehydrogenase Deficiency

Trifunctional Protein Deficiency

Very Long-Chain Acyl-CoA Dehydrogenase Deficiency

3-Hydroxy-3-Methylglutaric Aciduria

3-Methylcrotonyl-CoA Carboxylase Deficiency

Beta-Ketothiolase Deficiency

Glutaric Acidemia, Type I

Holocarboxylase Synthtase Deficiency

Isovaleric Acidemia

Methylmalonic Acidemia (Cobalamin Disorders)

Methylmalonic Acidemia (Methymalonyl-CoA Mutase Deficiency)

Propionic Acidemia

Congenital Adrenal Hyperplasia

Primary Congenital Hypothyroidism

Beta-Thalassemia

SC Disease

Sickle Cell Disease

Mucopolysaccharidosis Type-I

Pompe Disease

Adrenoleukodystrophy

Biotinidase Deficiency

Classic Galactosemia

Cystic Fibrosis

Severe Combined Immunodeficiency

Spinal Muscular Atrophy

500

I am a parent who brings their 8 day old into your office and you in pre-charting have discovered that my child tested positive for GALT. Counsel me.

A meaningful discussion requires adequate provider knowledge regarding the disease in question, attributes of the screening test (positive predictive value), and next steps in evaluation and/or treatment.


Reflex testing is already being performed

500

This channel specializes in 3D animation videos of traditional nursery rhymes and original children's songs. As of July 2025, it is the 3rd most-subscribed and 2nd most-viewed channel on YouTube.

CoComelon

500

This musical re-imagines Romeo and Juliet through the lives of the modern day Jets and Sharks.

West-Side Story