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NLE
Auto-antigens
Auto-antibodies
Cardiac Legions
Cutaneous NLE
100
Also known as a Newborn
What is neonate?
100
Anti-Ro (SSA) , Anti-La (SSB)
What are auto-antibodies?
100
Calrecticulin
What is an autoantigenic calcium-binding protein?
100
CCHB
What is The characteristic cardiac lesion of NLE?
100
Skin legions
What is a characteristic feature of Cutaneous NLE?
200
IgG
What is the immunoglobulin associated with this disease?
200
Placenta
What is the route by which antibodies are transmitted to the fetus?
200
CCHB
What is the disease that anti-Ro antibodies are associated with? What is complete congenital heart block?
200
1 in 15,000 to 1 in 22,000 births
What is the number of isolated incidences of CCHB
200
Ratio of 3:1
What is the ratio of female:male who have Cutaneous NLE?
300
Cardiac, dermatological, and hepatic manifestations
What are the clinical manifestations of NLE?
300
Small RNA protein complexes
What are Anti-Ro and anti-La autoantibodies are directed against ?
300
anti-52 kd Ro and anti-La antibodies
What are the antibodies associated with the greatest risk of having CCHB?
300
An absent atrioventricular (AV) node
What is the histopathology of hearts with CCHB?
300
papulosquamous lesions and annular erythema lesions
What are the characteristic legions of cutaneous NLE?
400
Complete congenital heart block
What is the cause of mortality in NLE?
400
One is associated with the Ro protein and the other is independent of Ro.
What are the two forms of La proteins?
400
An antibody produced by an organism in response to a constituent of its own tissues.
What is an auto-antibody?
400
The AV node was well form and normally situated
What is histopathology of a healthy heart?
400
Hepatomegly
What is an enlarged liver?
500
skin and conducting system of the heart
What are the clinical features by which NLE can be recognized?
500
U1-ribonucleoprotein
What is an auto-antigen?
500
Disease where immune system attacks the body.
What is an autoimmune disease?
500
Plasmapheresis and dexamethasone
What is the recommended treatment for mothers with anti-Ro and anti-La antibodies?
500
Helps antibodies and phagocytic cells to clear pathogens from an organism .
What is the function of complement?