neuro 3

riluzole

100

MOA/use/admin

inhibit glutamate/excitatory neurons

ALS

PO 

200

AE

GI upset

Hepatic failure

CNS depression/dizzy

neutropenia 

300

nurs considerations

monitor LFT, CBC

risk infection - edu on prevention

prolong survival for more than 3-6 months 

Guillain barre syndrome

100

What is it? Caused by?

usually occurs after an infection

autoimmune disease causing attack on peripheral myelin = rapid demyelinaiton 

200

S/SX

weak/paralysis

paresthesia

pain

decrease reflexes

bulbar weakness

fluctuations in HR/BP 

300

complication

respiratory failure

ANS dysfunction

DVT

urine retention

400

TX

if infection: use antibiotics/antivirals

corticosteroids to decrease inflammation 

plasmapheresis

IVIG

amyotrophic lateral sclerosis (ALS)

100

What is it? Caused by?

motor neuron loss @ spinal cord/lower brainstem d/t nerve overexcitation (cell injury, neuron degeneration)

200

s/sx

Depend on location: fatigue, progressive weakness (eventual paralysis), cramps, fasciculation (twitching), ataxia 

300

TX

riluzole - NO CURE