Shake it off
Condition (caused by toxicity) that presents with progressive parkinsonism, ataxia, dysarthria, and bulbar dysfunction
MRI: bilateral globus pallidus hyperintensities
What is manganese toxicity
Most common cause of winged scapula
Long thoracic nerve injury
Cells that produce and facilitate the movement of CSF
Disease modifying therapy known to cause lipoatrophy
glatiramer acetate
Father of Modern Neurology
Who is Jean Martin Charcot
DBS stimulation locations used to treat Parkinson's disease and how do they help
VIM: improves tremor
GPI or subthalamic nucleus: improves tremor, bradykinesia and rigidity
Disease associated with SOD1 mutations on Chromosome 21
Where aquaporin 4 channels are located
astrocyte foot processes
medication that inhibits voltage dependent potassium channels to improve nerve conduction in MS
"It's all coming back to me now", "Because you loved me" and "The power of love" and the condition associated
Who is Celine Dion and what is SPS (Stiff person syndrome)
Gene associated with hyperekplexia in which a patient has a sudden exaggerated startle response followed by prolonged rigidity and apnea, usually in response to auditory and tactile stimuli
What is glycine receptor a-1 subunit (GLRA-1)
Mechanism of action of onasemnogeneabeparvovec in SMA
rare leukodystrophy caused by mutations in GFAP gene, resulting in accumulation of abnormal filaments (Rosenthal fibers) in astrocytes
What is Alexander disease?
concentric alternating bands of preserved and absent myelination on imaging
What is Balo's concentric sclerosis
Localization of brain function and mapping of different brain regions by...
Who is Paul Broca and Carl Wernicke
Condition associated with CAG trinucleotide expansion in the ATN1 gene causing late onset (age 30 on average) ataxia, myoclonic epilepsy, and dementia. Most commonly in japanese
What is dentatrorubral pallidoluysian atrophy
Repetitive nerve stimulation findings of MG
Decremental response (CMAP decrement>10%) with 2-3 Hz stimulation
Primary function of the transverse temporal gyrus or Hersch's gyrus
Primary auditory cortex
Receives bilateral auditory input so unilateral lesions to this area do not lead to auditory disturbances
Syndrome presenting with bilateral upper extremity paralysis and preserved lower extremity strength due to bilateral ACA-MCA border zone infarcts
Man in the barrel syndrome
Real world neurological condition described by Alexander Dumas in the count of Montecristo
"Sight and hearing were the only two senses which, like two sparks, still lit up this human matter, already three quarters moulded for the tomb. Moreover only one of these two senses could reveal to the outside world the inner life, which animated this statue.... He was a corpse with living eyes, and at times, nothing could be more terrifying than this marble face out of which anger burned or joy shone
What is locked in syndrome?
Rare epilepsy syndrome seen after recovery from hypoxic ischemic injury with action induced myoclonus as main symptom
What is Lance Adams syndrome
Medication for LEMS that blocks presynaptic potassium channels, thus prolonging action potentials to give more time for calcium channels to remain open to promote Ach release into NMJ
Amifampridine
Thalamic nucleus that relays sensation except for the face
Ventral posterior lateral (VPL)
Condition associated with ischemic strokes, seizures, headaches, elevated CSF lactate and MT-TL1 mutations
Roman general and dictator whom the chronicler Plutarch described as being afflicted with “distemper in the head” and noted that he once fell into a fit in which “his body trembled, and some of the papers he held dropped out of his hands.”
Who is Julius Caesar