The Visual System
The Basal Ganglia
Clinical Connections
The Somatosensory System
Cranial Nerves
100

These particles of electromagnetic energy are the physical stimulus detected by photoreceptors in the retina.

What are photons?

100

This neurotransmitter from the substantia nigra pars compacta modulates striatal activity.

What is dopamine? 

100

Degeneration of dopaminergic neurons in the substantia nigra pars compacta leads to this disorder.

What is Parkinson's disease?

100

This cortical region occupies the postcentral gyrus?

What is the primary somatosensory cortex (S1)?

100

This cranial nerve controls most eye movements.

What is oculomotor (CN III)?

200

These cells are the first in the retina to fire action potentials.

What are retinal ganglion cells (RGCs)?

200

This structure serves as the primary input nucleus of the basal ganglia.

What is the striatum?

200

A lesion of this region disrupts relay of visual information to the primary visual cortex.

What is the lateral geniculate nucleus (LGN)?

200

This type of peripheral receptor converts physical deformation of the skin, such as pressure or vibration, into neural signals.

What is mechanoreceptor?

200

Extending from the brainstem to the thoracic and abdominal organs, this is the longest cranial nerve.

What is vagus (CN X)?

300

This small depression in the retina contains the highest density of cones and provides the sharpest visual acuity.

What is the fovea?

Remember: rodents are non-foveate

300

The globus pallidus pars interna and this midbrain structure form the main output nuclei of the basal ganglia.

What is the substantia nigra pars reticulata?

300

Failure to detect two closely spaced points on the skin indicates dysfunction in this sensory pathway.

What is dorsal column-medial lemniscus (DCML)?

300

This sensory modality relies on mechanoreceptors in muscles and tendons to detect body position and movement.

What is proprioception?

300

Testing shoulder shrug against resistance assesses this cranial nerve.

What is accessory (CN XI)?

400

Fibers from this half of each retina cross at the optic chiasm. 

What is the nasal retina?

400

The indirect pathway follows this sequence (starting in the striatum).

What is:

Striatum (D2-MSNs) --> GPe --> STN --> SNr/GPi

400

Hyperactivity in cortico-striato-thalamo-cortical loops contributes to the intrusive thoughts and repetitive behaviors characteristic of this condition.

What is obsessive compulsive disorder (OCD)?

400

Fine touch and proprioceptive information from the body synapse in this thalamic nucleus on the way to primary somatosensory cortex?

What is the VPL (ventral posterior lateral)?

400

While the glossopharyngeal (CN IX) and vagus (CN X) nerves contain nearly all functional fiber types, this is the one classification they do not include.

What is somatic motor (GSE, general somatic efferent)?

500

The ventral visual stream, also called the "what" pathway, follows this sequence. 

What is:

retina --> optic nerve --> LGN --> V1 --> V2--> V4

500

During stop-signal or Go/No-Go tasks, this basal ganglia pathway is rapidly recruited to cancel a planned movement?

What is the hyperdirect pathway? Ctx --> STN

500

Disinhibition of the thalamus due to infarct of the subthalamic nucleus produces this violent flinging movement of the limbs.

What is hemiballismus? 

500

Pain and temperature information from the body decussates at this location.

What is the spinal cord? (STT)

500

This pair of cranial nerves together conveys gustatory information from the tongue.

What is facial (CN VII; anterior tongue) and glossopharyngeal (CN IX: posterior tongue)?