Neurocognitive meds

I/MOA

100

donepezil indication and MOA?

alzeimers (mild-severe)

CNS selective, reversible and noncompetitive inhibitor of AChE

200

pramipexole indication and MOA?

parkinsons, restless leg syndrome 

non ergot DA agonist stimulating DA activity 

300

memantidine indication and MOA

alzeimers 

moderate affinity noncompetitive NMDA receptor antagonist 

400

ropinirole indication and MOA?

parkinsons, restless leg syndrome 

stimulates postsynaptic DA receptors in the brain 

500

carbidopa/levadopa indication and MOA?

parkinsons 

crosses BBB and converted to DA inhibit peripheral breakdown plasma breakdown of levadopa making more available 

DF/PK

100

sinemet DF?

PO

200

requip DF and PK?

PO 

renal 

300

Namenda DF and PK?

PO

renal 

400

mirapex DF and PK?

PO 

renal 

500

aricept DF?

PO, patch, ODT

ADR/DI

100

donepezil ADR and DI?

N/V/D, application site rxn, insomnia, prolonged QTC, bradycardia 

3A4, 2D6, anticholinergic, NSAID 

200

pramipexole ADR and DI?

C/N/V, dizzy, drowsy, HA, insomnia, augmentation, impulse control disorders, ortho hypo, hallucinations, dyskinesia 

OCT2, anti-psych agents 

300

memantine ADR and DI?

confusion, HA, dizzy, agitation, delusion, hallucinations, CNS effects, SJS, DVT, hepatitis, liver failure 

OCT2, Na bicarb, other NMDA antags 

400

ropinirole ADR and DI?

HTN/hypoTN, N/V, infection, dizzy, drowsy, sleep attacks, WD syndrome, poor impulse control, ortho hypo, back pain, augmentation

1A2 (smoking), antipsych meds 

500

carbidopa/levodopa ADR and DI?

ortho hypo, C/N, depression, dizzy, HA, increased SCr, BUN, WD syndrome 

MAOI within 14d

CI/random

100

Aricept CI?

piperidine derivatives 

200

Which neuro med is available in a patch?

Aricept (donepezil)

300

Which neuro med has DI with 3A4 and 2D6?

Aricept (donepezil)

400

Which meuro med has DI with 1A2?

Requip (ropinirole)

500

Which neuro med do you need to separate from iron supplements?

Sinemet (carbidope/levadopa)

PC/M

100

aricept PC and M?

do not crush or chew, take at bedtime, avoid heat sources with patch

mental status, wt, GI intolerance, GI bleed 

200

mirapex PC and M?

do not chew or crush, impulse control issues, titrate slowly, avoid alc 

vital signs, wt changes, BP, behavior 

300

Namenda PC and M?

do not crush or chew, avoid abrupt d/c titrate slowly, do not mix oral soln with any other liquids 

cognitive fx

400

requip PC and M?

do not crush or chew, cation impulsive behavior, smoking interactions 

BP, daytime alertness, fall risk, behavior 

500

sinemet PC and M?

do not crush or chew, avoid high protein intake, separate from iron supplements

hepatic fx, CBC, SCr, BUN, BP, mental status