Dopaminergic
- Levodopa/Carbidopa
What is the MOA of dopamine agonist medications?
MOA: Unknown
- Parkinsons of course
What Parkinson's medication is classified as an anticholinergic (Generic)?
- Benztropine (Cogentin)
What is the drug under MAO-B inhibitor?
- Selegiline
What primary neurotransmitter affects PD?
What are the two medications under the drug class dopamine agonist?
- Pramipexole (mirapex)
- Apomorphine ( Apokyn)
What is the medication under the drug class COMT inhibitor?
- Entacapone
What is the MOA of Cogentin (Brand name)
- Blocks cholinergic effects
Would you give this medication in the morning or at night? why?
- At night. This medication may cause insomnia
What is the MOA of a dopaminergic medication?
- MOA: increases dopamine synthesis
Provide the patient education for the use of dopamine agonists.
- Take with food to reduce nausea
What is the MOA of a COMT inhibitor?
Besides Parkinsons disease what other reasons would this medication indicated for
- Medication-induced EPS
- Blocks the breakdown of dopamine by blocking MAO-B
What are the patient teachings you would give to a patient taking levodopa/carbidopa?
- This medication may have the wearing-off effect where symptoms return prior to the time for the next dose
What are the SE/AE of dopamine agonists?
- Constipation
- Nausea
- Dizziness
- Drowsiness
- Insomnia
Entacapone is often added to _____ and other Parkinsons' regimens to reduce _______
- Levodopa/Carbidopa
- Wearing off-effect
Provide 5 anticholinergic effects
Decreased SLUDGE
- Administer early in the day
- Avoid foods that contain tyramine (Cheese, wine)
- Caution for interaction with TCA and other related mental health medications
What are the SE/AE of Levodopa/Carbidopa?
- Nausea and vomiting
- Dyskinesia
- Orthostatic hypotension
- psychosis
(IT MAY OR MAY NOT BE RELATED TO DOPAMINE AGONIST) What is orthostatic hypotension and dyskinesia
- Orthostatic hypertension is a type of high blood pressure that occurs when someone goes from lying down to standing.
- Tounge protrusion, Facial grimacing, lip smacking, excessive eye movement.
What is a COMT inhibitor? (IDK if this information is needed)
- The COMT inhibitors, tolcapone and entacapone, are a new class of Parkinson's medications. By inhibiting the enzyme catechol-o-methyl-transferase (COMT), they prevent peripheral degradation of levodopa, allowing a higher concentration to cross the blood-brain barrier.
Benztropine is primarily used for the symptom of _____
- Tremor
What is MAO-B?
- MAO-B is an enzyme
- MAO-B inhibitors stop this enzyme so that more dopamine becomes available to treat your symptoms.