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Brain matters
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Cradle to the Grave
100
This neurotransmitter system facilitates sexual arousal
a. GABAergic
b. Glycinergic
c. Serotonergic
d. Dopaminergic
e. Glutamatergic
d. Dopaminergic
Source: Prite 2019
100
60 y/o right-handed M, getting lost, only writes on right half of paper. Left-sided hemineglect.
Where is the lesion?
RIGHT PARIETAL LOBE
Ninja (8x)
100
In patients with epilepsy, which of the following is the most common comorbid psychiatric disorder?
a. schizophrenia
b. bipolar
c. MDD
d. GAD
e. borderline personality disorder
c. MDD
Source: Prite 2019
100
This region of the cerebral cortex is located deep within the lateral sulcus
Insula
100
The rapid learning demonstrated by children during the school-age years is paralleled neurodevelopmentally by this brain processes
A. Increase in white matter
B. Increase in gray matter
C. Rapid expansion in volume
D. Prefrontal cortical pruning
E. Stability of Electroencephalograph
A. Increase in white matter
200
Dopamine release in this structure represents common final event assx with reinforcing effects of addictions
Nucleus Accumbens
Source: Ninja (4x)
200
Previously pleasant mom becomes profane and irresponsible over 6 months. Most likely a
pathology in:
Frontal Lobe
Source: Ninja (2x)
200
Restless leg syndrome is associated with deficiency in which of the following substances
a. iron
b. cooper
c. glucose
d. thiamine
e. cyanocobalamine
e. cyanocobalamine
Source: Prite 2019
200
This MRI image is from a 65 yo with progressive cognitive decline. LP shows normal opening pressure and was otherwise normal. Which is likely to be found on examination?
a. gait apraxia
b. cogwheeling
c. expressive aphasia
d. alien hand syndrome
e. reduced vertical eye movements
a. gait apraxia
200
Development of brain grey-matter volume peaks at this stage
A. Early Childhood
B. Late Childhood
C. Early Adulthood
D. Late Adulthood
E. 3rd Trimester in utero
B. Late Childhood
300
Role of glycine at NMDA Receptor
Obligate coagonist
Source: Ninja (2x)
Opening of NMDA receptor require:
1.AMPA to depolarize membrane to dislodge Mg
2. 2 molecules of Glycine to bind
3. 2 molecules Glutmate to bind
300
A pituitary tumor that protrudes through the diaphragmatic sella is most likely to cause?
Bitemporal hemianopsia
Source: Ninja
300
Patients with which of the following neurocogntive disorders are more likely to develop severe EPS from anti psychotic medications?
a. Prion disease
b. alzheimer disease
c. lewy body disease
d. cerebrovascular disease
e. frontotemporal lobar degeneration
c. lewy body disease
300
The lesion shown below are most consistent with the following clinical presentation
a. ataxia, clumsy hand
b. rigidity, bradykinesia, tremor
c. apathy, hyper sexuality, hyperphagia
d. amnesia, confabulation, lack of insight
e. progressive aphasia, personality changes
d. amnesia, confabulation, lack of insight
Korsakoff:
-caused by thiamine deficiency
-chronic, irreversible
-assx with b/l necrosis of mammillary bodies
300
Among Neurodevelopmental risk factors for aggression in male children, the evidence is strongest for gene/environment interaction between maltreatment and genes for this
A. Oxytocin
B. Serotonin-transporter
C. Dopamine-transporter
D. Monoamine Oxidase A
E. Brain-Derived Neurotrophic Factor
D. Monoamine Oxidase A
400
Biogenic amine made in locus coeruleus
NE
Source: Ninja
Serotonin: raphe nucleus
Ach: nucleus basalis of Meynert
Dopamine: substantia nigra and VTA
400
Aphasia w/ effortful fragmented, non-fluent, telegraphic speech, is seen in a lesion where?
Posterior Frontal Lobe (Broca's area)
400
25 year old with DM presents with ptosis that worsens towards the end of the day. The pt reports double vision while reading. Sx improve upon awakening the next morning. Denies pain and eye exam otherwise unremarkable. Which of the following is the most likely cause of presentation?
a. optic glioma
b. multiple sclerosis
c. third nerve palsy
d. myasthenia gravis
e. horner's syndrome
D. myasthenia gravis
Source: PRITE 2019
400
Tau staining of hippocampal tissue from pt with progressive dementia shown below. What is the diagnosis
Alzheimer's
-image shows Neurofibrillary tangles made from tau protein
-also see beta amyloid plaques in Alzheimer as well
400
This is the most frequently seen comorbid condition in children with autism
A. Selective mutism
B. Intellectual disability (mental retardation)
C. Early-onset schizophrenia
D. OCD
E. ADHD
B. Intellectual disability (mental retardation)
500
This neurotransmitter is last to mature in CNS of children and adolescents
Cholinergic
Source Ninja (2x)
500
Inability to recognize faces is caused by lesion in this structure
Fusiform Gyrus
Source: Ninja
500
A 37 year old pt is evaluated for progressive spastic paraplegia. The pt also reports new onset visual loss. MRI of spine is notable for longitudinal lesion in cervical spinal cord, and MRI of brain shows enhancement in the optic nerve. Antibodies to what are assx with this syndrome
Aquaporin 4
Source: Prite 2019
500
A lesion in the red lines below leads to this type of aphasia
Conduction aphasia
(Fluent speech w preserved comprehension, inability to repeat statements is consistent with
what type of aphasia)
500
Research studies have found an association between Alzheimers Disease and the accumulation of this protein inside cortical neurons
A. Amyloid
B. Tau
C. Fibrillin
D. Presenelin
E. Neuropeptide Y
B. Tau