Receptors
These ion channels are responsible for the depolarization phase of the action potential.
What are voltage-gated sodium channels?
You'll find these cell bodies scattered across the raphe nucleus. They express the 5HT1A receptor.
What are serotonergic cell bodies?
SSRIs inhibit this target.
What is the serotonin transporter?
This therapeutic was the first SSRI on the market. It was FDA approved in 1987.
What is fluoxetine (or Prozac)?
Lights, camera, action! This technique - popularized in the early 2010s - revolutionized in vivo circuit-mapping.
What is optogenetics?
This receptor functions both as a presynaptic autoreceptor and a postsynaptic heteroreceptor. It can be found on cell bodies of serotonin neurons.
What is the 5HT1A receptor?
The dopaminergic projections stem from these two regions.
What is the ventral tegmental area and the substania nigra?
Salvinorin A, the main psychotropic molecule in the salvia divinorum plant, selectively binds this receptor.
What is the kappa opioid receptor?
What is Cymbalta?
This technique, near and dear to the Andrews' Lab, can be used to multiplex neurotransmitter measurements in vivo.
What is microdialysis?
This receptor is the only ion channel in a family of 14. The remaining receptors are GPCRs.
What is the 5HT3 receptor?
The norepinephrine projections stem from these two regions.
What is the locus coeruleus and the lateral tegmental field?
Esketamine, an antagonist at this receptor, can provide rapid antidepressant relief in treatment-resistant patients.
What is the NMDA receptor?
While typically used for smoking cessation, this norepinephrine-dopamine reuptake inhibitor can be prescribed to treat MDD.
What is bupropion (Wellbutrin)?
Snip snip! Through this technique, the Cas9 enzyme recognizes specific DNA sequences, allowing for gene editing.
What is CRISPR?
While this receptor can have many isoforms, it is a pentameric ligand-gated ion channel that can bind a variety of drugs, including alcohol.
What is the GABAA Receptor?
What are the forebrain cholinergic nuclei and the brainstem cholinergic nuclei?
These two G-protein coupled receptors can differentially bind THC and CBD, two ingredients that can be found in hemp.
What are CB1 and CB2 receptors?
This tuberculosis medication was coincidentally found to improve mood and subsequently used as an antidepressant.
What is iproniazid?
In this technique, injection of a "designer drug" allows DREADD activation, enabling selective control of specific neural populations.
What is chemogenetics?
These receptors are located on medium spiny neurons in the striatum. Their pathways have antagonistic effects.
What are D1 and D2 receptors?
You'll find the only histaminergic cell bodies in this nucleus.
What is the tuberomammilary nucleus?
What is the dopamine transporter?
This preferential presynaptic 5HT1A receptor full agonist can be used to treat generalized anxiety disorder.
What is buspirone (Buspar)?
In FSCV, neurotransmitters are detected via oxidation at the electrode surface. This amount of electrons is involved in the oxidation of serotonin.
What is one?