Neuroscience of Substance Use Disorders Jeopardy

Neurotransmission 101

100

THIS is the space between neurons

Synaptic space or Synaptic cleft

_{U.S Department of Health and Human Services, National Institute of Health, & National Institute on Drug Abuse. (march 2020). The Brain: Understanding Neurobiology Through the Study of Addiction. Colorado Springs, OR: BSCS Development Team. Pg. 43}

200

THIS protects the brain from substances

The blood-brain barrier

_{U.S Department of Health and Human Services, National Institute of Health, & National Institute on Drug Abuse. (march 2020). The Brain: Understanding Neurobiology Through the Study of Addiction. Colorado Springs, OR: BSCS Development Team. Pg. 44}

300

THIS is a molecule that is released from a neuron to relay information to another cell

Neurotransmitter

_{U.S Department of Health and Human Services, National Institute of Health, & National Institute on Drug Abuse. (march 2020). The Brain: Understanding Neurobiology Through the Study of Addiction. Colorado Springs, OR: BSCS Development Team. Pg. 46}

400

Neurotransmitter molecules are stored in THIS

Vesicles

_{U.S Department of Health and Human Services, National Institute of Health, & National Institute on Drug Abuse. (march 2020). The Brain: Understanding Neurobiology Through the Study of Addiction. Colorado Springs, OR: BSCS Development Team. Pg. 46}

500

The released neurotransmitter is either (1) degraded by enzymes in the synaptic cleft or (2) taken back by active transport through THIS

Transporter or reuptake pump

_{U.S Department of Health and Human Services, National Institute of Health, & National Institute on Drug Abuse. (march 2020). The Brain: Understanding Neurobiology Through the Study of Addiction. Colorado Springs, OR: BSCS Development Team. Pg. 47}

Drugs Change the Way Neurons Communicate

100

(True/False) Drugs interfere with neurotransmission, which impacts how the brain and body function

True

_{U.S Department of Health and Human Services, National Institute of Health, & National Institute on Drug Abuse. (march 2020). The Brain: Understanding Neurobiology Through the Study of Addiction. Colorado Springs, OR: BSCS Development Team. Pg. 66}

200

THESE 2 factors are especially important in determining how fast a drug reaches the brain

(1) the dose of the drug and (2) the route of administration

_{U.S Department of Health and Human Services, National Institute of Health, & National Institute on Drug Abuse. (march 2020). The Brain: Understanding Neurobiology Through the Study of Addiction. Colorado Springs, OR: BSCS Development Team. Pg. 69}

300

(True/False) Everyone will respond the same way to a given drug dose

False

_{U.S Department of Health and Human Services, National Institute of Health, & National Institute on Drug Abuse. (march 2020). The Brain: Understanding Neurobiology Through the Study of Addiction. Colorado Springs, OR: BSCS Development Team. Pg. 69}

400

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Chronic alcohol consumption gradually makes receptors hypersensitive to THIS while desensitizing THAT receptors (2 PART ANSWER)

Glutamate, GABA

_{U.S Department of Health and Human Services, National Institute of Health, & National Institute on Drug Abuse. (march 2020). The Brain: Understanding Neurobiology Through the Study of Addiction. Colorado Springs, OR: BSCS Development Team. Pg. 68}

500

(2 PART ANSWER) Altered dopamine in THIS and THIS is the initial and one of the most important factors driving continued drug use

Ventral Tegmental Area (VTA) and the Nucleus Accumbens

_{U.S Department of Health and Human Services, National Institute of Health, & National Institute on Drug Abuse. (march 2020). The Brain: Understanding Neurobiology Through the Study of Addiction. Colorado Springs, OR: BSCS Development Team. Pg. 69}

The Natural Way

100

THESE are natural ways to increase Serotonin

(1) Healthy foods, (2) Exercise, (3) Sunlight, (4) Massage, (5) Positive Social Interaction, and (6) Engagement in positive pro-social activities

_{Healthline. (n.d.). 6 Ways to Boost Serotonin Without Medication. Retrieved July 15, 2019, from https://www.healthline.com/health/how-to-increase-serotonin}

200

THESE are ways to increase GABA naturally

(1) Sleep Hygiene, (2) Supplements such as Magnesium, (3) Exercise, (4) Yoga, (5) Meditate, (6) Overall working to depress your life

_{GABA: The Neurotransmitter That Dissolves Anxiety and Improves Sleep. How to raise your GABA naturally. Brooks, Spenser. https://blog.bulletproof.com/gaba-neurotransmitter-supplement-anxiety-sleep/}

300

THESE are natural ways to increase dopamine

(1) Sleep Hygiene, (2) Supplements such as Magnesium, (3) Exercise, (4) Yoga, (5) Meditate, (6) Overall working to destress your life

_{BrainMD Life. (2018, March 28). 7 Ways to Increase Dopamine, Focus, and Energy. Retrieved July 15, 2019, from https://www.brainmdhealth.com/blog/7-ways-to-boost-dopamine-focus-and-energy/}

400

THESE are ways to increase Norepinephrine naturally

(1) exercising for at least half an hour each day, (2)  taking a cold shower, (3) getting plenty of sleep

_{Addiction.com. (2018, April 16). Natural Ways to Produce Norepinephrine. Retrieved July 15, 2019, from https://www.addiction.com/73986/natural-ways-produce-norepinephrine/}

500

(PERSONAL ANSWER) THIS is a way I have found to improve my mood and psychological wellbeing without drugs

Examples: Exercise, Artistic expression, Creativity, Accomplishing goals, engaging in enjoyable activities, etc.

Drugs and Neurotransmitters

100

THIS drug binds to Acetylcholine receptor sites and Dopamine receptor sites, reinforcing it's ingestion

Nicotine 

_{U.S Department of Health and Human Services, National Institute of Health, & National Institute on Drug Abuse. (march 2020). The Brain: Understanding Neurobiology Through the Study of Addiction. Colorado Springs, OR: BSCS Development Team. Pg. 67}

200

THESE are the primary Neurotransmitters Alcohol effects

GABA, Acetylcholine, Serotonin, and Glutamate

_{U.S Department of Health and Human Services, National Institute of Health, & National Institute on Drug Abuse. (march 2020). The Brain: Understanding Neurobiology Through the Study of Addiction. Colorado Springs, OR: BSCS Development Team. Pg. 68}

300

THIS drug actually causes the release of dopamine and blocks itself reuptakes resulting in a quick and prolonged rise in dopamine

Methamphetamine 

_{U.S Department of Health and Human Services, National Institute of Health, & National Institute on Drug Abuse. (march 2020). The Brain: Understanding Neurobiology Through the Study of Addiction. Colorado Springs, OR: BSCS Development Team. Pg. 66}

400

THIS is the primary neurotransmitter Cannabis impacts

Anandamide

_{U.S Department of Health and Human Services, National Institute of Health, & National Institute on Drug Abuse. (march 2020). The Brain: Understanding Neurobiology Through the Study of Addiction. Colorado Springs, OR: BSCS Development Team. Pg. 69}

500

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(3 WORD ANSWER) THIS produce feelings of pleasure by altering neurotransmission in the reward system that produce Dopamine

Drugs of Abuse

_{U.S Department of Health and Human Services, National Institute of Health, & National Institute on Drug Abuse. (march 2020). The Brain: Understanding Neurobiology Through the Study of Addiction. Colorado Springs, OR: BSCS Development Team. Pg. 66}

Major Neurotransmitters in the Body

100

THIS causes muscle contraction and regulates memory and is most instances is excitatory

Acetylcholine

_{U.S Department of Health and Human Services, National Institute of Health, & National Institute on Drug Abuse. (march 2020). The Brain: Understanding Neurobiology Through the Study of Addiction. Colorado Springs, OR: BSCS Development Team. Pg. 48}

200

THIS produces feelings of pleasure through the brain's reward circuitry

Dopamine

_{U.S Department of Health and Human Services, National Institute of Health, & National Institute on Drug Abuse. (march 2020). The Brain: Understanding Neurobiology Through the Study of Addiction. Colorado Springs, OR: BSCS Development Team. Pg. 48}

300

THIS is part of the fight or flight response, regulates blood pressure and calmness.

Norepinephrine

_{U.S Department of Health and Human Services, National Institute of Health, & National Institute on Drug Abuse. (march 2020). The Brain: Understanding Neurobiology Through the Study of Addiction. Colorado Springs, OR: BSCS Development Team. Pg. 48}

400

THIS is important in producing sleep, reducing anxiety, and forming memories

GABA

_{U.S Department of Health and Human Services, National Institute of Health, & National Institute on Drug Abuse. (march 2020). The Brain: Understanding Neurobiology Through the Study of Addiction. Colorado Springs, OR: BSCS Development Team. Pg. 48}

500

THIS is involved in functions including mood, appetite, and sensory perception.

Serotonin

_{U.S Department of Health and Human Services, National Institute of Health, & National Institute on Drug Abuse. (march 2020). The Brain: Understanding Neurobiology Through the Study of Addiction. Colorado Springs, OR: BSCS Development Team. Pg. 48}