Mechanism of Action
Metoprolol
What is "Prevents beta1 receptor activation resulting in reduced HR, force of contract, speed of impulses through the AV node"?
The four pharmacokinetic processes
What are absorption, distribution, metabolism, and excretion?
Maximal efficacy
What is the largest effect that a drug can produce?
Adverse drug reaction definition
Naloxone
What is "Interferes with the action of opioids by blocking opioid receptors"?
The therapeutic objective of drug therapy
What is maximum benefit with minimal harm?
Affinity
What is "The strength of attraction between drug and receptor"?
Literally, “a disease produced by a physician”; also used to refer to a disease produced by drugs or drug-induced disease
What is iatrogenic effect?
Penicillin
What is "Weakens bacterial cell wall causing the bacteria to take up excessive amounts of water and rupture"?
The Big Three
What are effectiveness, safety, and selectivity?
Intrinsic activity
What is "The ability of a drug to activate receptors"?
This ADR can cause life-threatening dysrhythmias
What is prolonged QT interval?
Ondansetron
What is "Prevents emesis by blocking the serotonin receptors in the chemoreceptor trigger zone (CTZ) and antagonizing the serotonin receptors on the afferent vagal neurons that travel from the upper GI tract to the CTZ"?
P-glycoprotein function
What is "transports drugs out of cells"?
Therapeutic index ratio
What is "LD50:ED50"?
The leading cause of liver failure in the US
What is hepatotoxic drugs?
Insulin (3 total)
What is "Promotes cellular uptake of glucose (decreases glucose levels), converts glucose into glycogen and promotes energy storage, and moves potassium into cells (along with glucose)"?
Blank cannot cross cell membranes
What is ions?
Two methods in which receptor sensitivity is changed
What are continuous activation and continuous inhibition?
The 4 disciplines tasked with ADR prevention
Who are pharmacy, provider/prescriber, nurse, and patients/families?